Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the
concept of malignant pathologies as being solely genetic-based conditions. The epigenetic …

Background: Epigenetic mechanisms alter gene expression and regulate vital cellular
processes that contribute to the onset and progression of major dental diseases. Their …

Abstract Changes in DNA methylation, whether hypo‐or hypermethylation, have been
shown to be associated with the progression of colorectal cancer. Methylation changes …

Multicomponent molecular modifications such as DNA methylation may offer sensitive and
specific cervical intraepithelial neoplasia and cervical cancer biomarkers. In this study, we …

This study was designed to assess the epigenetic alterations in blood cells, induced by
occupational exposure to multi-wall carbon nanotubes (MWCNT). The study population …

Background Recent studies have found out that the initiation and progression of cancer,
traditionally seen as a genetic disease, is now realized to involve epigenetic abnormalities …

Genomic instability underlies the transformation of host cells toward malignancy, promotes
development of invasion and metastasis and shapes the response of established cancer to …

The aberrant DNA methylation of the tumor suppressor genes involved in DNA Damage
Response (DDR) signaling and cell cycle regulation may lead to the tumorigenesis. Our …

Background: Secreted frizzled-related protein (SFRP) genes, new tumor suppressor genes,
are negative regulators of the Wnt pathway whose alteration is associated with various …

Background: LATS1 (Large Tumor Suppressor, isoform 1) is a gene that forms a complex
with the cyclin-dependent kinase, CDK1, and regulates cell cycle progression. Genetic …