The role of estrogen receptors and their signaling across psychiatric disorders
Increasing evidence suggests estrogen and estrogen signaling pathway disturbances
across psychiatric disorders. Estrogens are not only crucial in sexual maturation and …
across psychiatric disorders. Estrogens are not only crucial in sexual maturation and …
[HTML][HTML] Brain-derived estrogen and neural function
Although classically known as an endocrine signal produced by the ovary, 17β-estradiol (E
2) is also a neurosteroid produced in neurons and astrocytes in the brain of many different …
2) is also a neurosteroid produced in neurons and astrocytes in the brain of many different …
The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
Background Previous studies show that antibiotic-mediated (abx) alteration of the gut
microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory …
microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory …
Cerebroprotection for acute ischemic stroke: looking ahead
PD Lyden - Stroke, 2021 - Am Heart Assoc
We search for ischemic stroke treatment knowing we have failed—intensely and often—to
translate mechanistic knowledge into treatments that alleviate our patients' functional …
translate mechanistic knowledge into treatments that alleviate our patients' functional …
Crosstalk of astrocytes and other cells during ischemic stroke
Stroke is a leading cause of death and long-term disability worldwide. Astrocytes structurally
compose tripartite synapses, blood–brain barrier, and the neurovascular unit and perform …
compose tripartite synapses, blood–brain barrier, and the neurovascular unit and perform …
From menopause to neurodegeneration—molecular basis and potential therapy
The impacts of menopause on neurodegenerative diseases, especially the changes in
steroid hormones, have been well described in cell models, animal models, and humans …
steroid hormones, have been well described in cell models, animal models, and humans …
Top priorities for cerebroprotective studies—a paradigm shift: report from STAIR XI
Despite years of basic research and pioneering clinical work, ischemic stroke remains a
major public health concern. Prior STAIR (Stroke Treatment Academic Industry Roundtable) …
major public health concern. Prior STAIR (Stroke Treatment Academic Industry Roundtable) …
[HTML][HTML] Estradiol and estrogen-like alternative therapies in use: The importance of the selective and non-classical actions
Estrogen is one of the most important female sex hormones, and is indispensable for
reproduction. However, its role is much wider. Among others, due to its neuroprotective …
reproduction. However, its role is much wider. Among others, due to its neuroprotective …
Zinc improves neurological recovery by promoting angiogenesis via the astrocyte‐mediated HIF‐1α/VEGF signaling pathway in experimental stroke
Y Li, T Ma, X Zhu, M Zhang, L Zhao… - CNS neuroscience & …, 2022 - Wiley Online Library
Background Ischemic stroke is a serious cerebrovascular disease with high morbidity and
disability. Zinc accumulation has been shown to play a vital role in neuronal death and …
disability. Zinc accumulation has been shown to play a vital role in neuronal death and …
Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice
Introduction Chronic neuroinflammation can exist for months to years following traumatic
brain injury (TBI), although the underlying mechanisms remain poorly understood. Methods …
brain injury (TBI), although the underlying mechanisms remain poorly understood. Methods …