Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

Lines of evidence from several studies have shown that increases in life expectancy are now
accompanied by increased disability rate. The expanded lifespan of the aging population …

The causal relationships between insulin levels, insulin resistance, and longevity are not
fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling …

Nutrients are necessary for life, as they are a crucial requirement for biological processes
including reproduction, somatic growth, and tissue maintenance. Therefore, signaling …

Humanin is a member of a new family of peptides that are encoded by short open reading
frames within the mitochondrial genome. It is conserved in animals and is both …

Model organisms have provided fundamental evidence that aging can be delayed and
longevity extended. These findings gave rise to a new era in aging research aimed at …

The mechanisms underlying biological aging have been extensively studied in the past 20
years with the avail of mainly four model organisms: the budding yeast Saccharomyces …

Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) or GDF15 is a divergent
member of the transforming growth factor beta (TGF-β) superfamily and mice expressing …