Today, RNA aptamers are being considered promising theranostic tools against a wide
variety of disorders. RNA aptamers can fold into complex shapes and bind to diverse …

Simple Summary Triple-negative breast cancer (TNBC) is an aggressive breast cancer
subtype with poor outcomes and limited therapeutic options. It is characterized by a more …

Simple Summary Glioblastoma multiforme is the most lethal form of brain cancer. To improve
patient outcomes, more effective treatments should be designed. Therefore, it is important to …

Nucleic acid aptamers are oligonucleotide chains with molecular recognition properties.
Compared with antibodies, aptamers show advantages given that they are readily produced …

RNA-based therapeutics (eg, mRNAs, siRNAs, microRNAs, ASOs, and saRNAs) have
considerable potential for tumor treatment. The development and optimization of RNA …

Abstract Glypican-3 (GPC3), a heparin sulfate proteoglycan, is a potential diagnostic and
therapeutic target for hepatocellular carcinoma. In this paper, a novel fluorescent aptasensor …

A novel series of quinazoline-based agents bearing triazole-acetamides 8a-l were designed
and synthesized. All the obtained compounds were tested for in vitro cytotoxic activities …

Increased levels of cathepsin B (CatB), a cysteine protease, have been associated with
different types of tumors, including prostate cancer. Hence, the identification of novel …

Embryonal rhabdomyosarcoma (ERMS) is the muscle-derived tumor retaining myogenic
ability. iSN04 and AS1411, which are myogenetic oligodeoxynucleotides (myoDNs) serving …

Injectable anticoagulants are widely used in medical procedures to prevent unwanted blood
clotting. However, many lack safe, effective reversal agents. Here, we present new data on a …