Ferrosenescence: the iron age of neurodegeneration?

A Sfera, K Bullock, A Price, L Inderias… - Mechanisms of ageing and …, 2018 - Elsevier
Aging has been associated with iron retention in many cell types, including the neurons,
promoting neurodegeneration by ferroptosis. Excess intracellular iron accelerates aging by …

The regulatory impact of RNA-binding proteins on microRNA targeting

S Kim, S Kim, HR Chang, D Kim, J Park, N Son… - Nature …, 2021 - nature.com
Argonaute is the primary mediator of metazoan miRNA targeting (MT). Among the currently
identified> 1,500 human RNA-binding proteins (RBPs), there are only a handful of RBPs …

miR-206/133b cluster: a weapon against lung cancer?

JY Pan, CC Sun, ZY Bi, ZL Chen, SJ Li, QQ Li… - … Therapy-Nucleic Acids, 2017 - cell.com
Lung cancer is a deadly disease that ends numerous lives around the world. MicroRNAs
(miRNAs) are a group of non-coding RNAs involved in a variety of biological processes …

[HTML][HTML] Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators

M Geretto, A Pulliero, C Rosano… - American journal of …, 2017 - ncbi.nlm.nih.gov
Chemo-resistance, which is the main obstacle in cancer therapy, is caused by the onset of
drug-resistant cells in the heterogeneous cell population in cancer tissues. MicroRNAs …

MiRNA-based therapeutic strategy in lung cancer

G Li, J Fang, Y Wang, H Wang… - Current pharmaceutical …, 2017 - ingentaconnect.com
Lung cancer is one of the most common malignant tumors in the world. Although advanced
therapies have been applied for the treatment of lung cancer, the prolongation of overall …

Peptides as epigenetic modulators: therapeutic implications

Y Janssens, E Wynendaele, W Vanden Berghe… - Clinical …, 2019 - Springer
Peptides originating from different sources (endogenous, food derived, environmental, and
synthetic) are able to influence different aspects of epigenetic regulation. Endogenous short …

Antibiotics-peptide conjugates against multidrug-resistant bacterial pathogens

AA David, SE Park, K Parang… - Current Topics in …, 2018 - ingentaconnect.com
The menace of multi-drug resistance by bacterial pathogens that are responsible for
infectious diseases in humans and animals cannot be over-emphasized. Many bacteria …

[HTML][HTML] Trading places: Peptide and small molecule alternatives to oligonucleotide-based modulation of microRNA expression

T Chaudhry, CR Coxon, K Ross - Drug Discovery Today, 2022 - Elsevier
It is well established that microRNA (miRNA) dysregulation is involved in the development
and progression of various diseases, especially cancer. Emerging evidence suggests that …

miR‑29b suppresses proliferation and induces apoptosis of hepatocellular carcinoma ascites H22 cells via regulating TGF‑β1 and p53 signaling pathway

YL Liu, WH Yang, BY Chen, J Nie… - International …, 2021 - spandidos-publications.com
Abstract MicroRNA (miR)‑29b is a key tumor regulator. It can inhibit tumor cell proliferation,
induce apoptosis, suppress tumor invasion and migration, thus delaying tumor progression …

Role of Epigenetics in Human Diseases

FA Azami, M Eslami, AM Ardekani - Molecular Mechanisms of …, 2023 - books.google.com
Epigenetic processes have been defined as heritable changes in gene expression and
chromatin structure without alternating coding sequences (1). Epigenetic changes are …