Review of advances in electrospinning-based strategies for spinal cord regeneration

Y Li, T Dong, Z Li, S Ni, F Zhou, OA Alimi, S Chen… - Materials Today …, 2022 - Elsevier
Spinal cord injury (SCI) is a devastating neurological condition, commonly leading to
physical and mental deficiencies, pain, other complications, and even death. Most recently …

[HTML][HTML] Nanoscale surface coatings and topographies for neural interfaces

Y Cho, Y Choi, H Seong - Acta Biomaterialia, 2024 - Elsevier
With the lack of minimally invasive tools for probing neuronal systems across spatiotemporal
scales, understanding the working mechanism of the nervous system and limited …

[HTML][HTML] Anisotropic 3D scaffolds for spinal cord guided repair: Current concepts

JPM Sousa, E Stratakis, J Mano, PAAP Marques - Biomaterials Advances, 2023 - Elsevier
A spinal cord injury (SCI) can be caused by unforeseen events such as a fall, a vehicle
accident, a gunshot, or a malignant illness, which has a significant impact on the quality of …

Function Follows Form: Oriented Substrate Nanotopography Overrides Neurite-Repulsive Schwann Cell–Astrocyte Barrier Formation in an In Vitro Model of Glial …

P Achenbach, L Hillerbrand, JL Gerardo-Nava… - Nano Letters, 2023 - ACS Publications
Schwann cell (SC) transplantation represents a promising therapeutic approach for
traumatic spinal cord injury but is frustrated by barrier formation, preventing cell migration …

TGFβ3 is neuroprotective and alleviates the neurotoxic response induced by aligned poly-l-lactic acid fibers on naïve and activated primary astrocytes

MK Gottipati, AR D'Amato, AM Ziemba, PG Popovich… - Acta biomaterialia, 2020 - Elsevier
Following spinal cord injury, astrocytes at the site of injury become reactive and exhibit a
neurotoxic (A1) phenotype, which leads to neuronal death. In addition, the glial scar, which …

Electrospun fiber scaffolds for engineering glial cell behavior to promote neural regeneration

DL Puhl, JL Funnell, DW Nelson, MK Gottipati… - Bioengineering, 2020 - mdpi.com
Electrospinning is a fabrication technique used to produce nano-or micro-diameter fibers to
generate biocompatible, biodegradable scaffolds for tissue engineering applications …

Polyaniline-polycaprolactone fibers for neural applications: Electroconductivity enhanced by pseudo-doping

FFF Garrudo, PE Mikael, CAV Rodrigues… - Materials Science and …, 2021 - Elsevier
Replenishing neurons in patients with neurodegenerative diseases is one of the ultimate
therapies for these progressive, debilitating and fatal diseases. Electrical stimulation can …

Electrical stimulation of neural-differentiating iPSCs on novel coaxial electroconductive nanofibers

FFF Garrudo, DES Nogueira, CAV Rodrigues… - Biomaterials …, 2021 - pubs.rsc.org
Neural tissue engineering strategies are paramount to create fully mature neurons,
necessary for new therapeutic strategies for neurological diseases or the creation of reliable …

Enhanced peripheral nerve regeneration by mechano-electrical stimulation

Y Tai, TI Tonmoy, S Win, NT Brinkley, BH Park… - npj Regenerative …, 2023 - nature.com
To address limitations in current approaches for treating large peripheral nerve defects, the
presented study evaluated the feasibility of functional material-mediated physical stimuli on …

Designing Electrical Stimulation Platforms for Neural Cell Cultivation Using Poly (aniline): Camphorsulfonic Acid

FFF Garrudo, RJ Linhardt, FC Ferreira, J Morgado - Polymers, 2023 - mdpi.com
Electrical stimulation is a powerful strategy to improve the differentiation of neural stem cells
into neurons. Such an approach can be implemented, in association with biomaterials and …