Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Wnt signaling pathway is one of the most important signaling pathways. The complexity of
Wnt signals and their functional role is crucial in development and growth. It is the most …

The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

Neural tube defects are severe congenital malformations affecting around one in every 1000
pregnancies. An innovation in clinical management has come from the finding that closure of …

The primary cilium has recently stepped into the spotlight, as a flood of data show that this
organelle has crucial roles in vertebrate development and human genetic diseases. Cilia …

The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a
critical, evolutionarily conserved process during development and organogenesis. Analyses …

Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and
tissue homeostasis. Misregulation of intracellular signal transduction can lead to …

G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

Neural-tube closure is a critical step of embryogenesis, and its failure causes serious birth
defects. Coordination of two morphogenetic processes—convergent extension and neural …

Planar polarity describes the coordinated polarisation of cells or structures in the plane of a
tissue. The patterning mechanisms that underlie planar polarity are well characterised in …