Shear stress-induced activation of von Willebrand factor and cardiovascular pathology

S Okhota, I Melnikov, Y Avtaeva, S Kozlov… - International Journal of …, 2020 - mdpi.com
The von Willebrand factor (vWF) is a plasma protein that mediates platelet adhesion and
leukocyte recruitment to vascular injury sites and carries coagulation factor VIII, a building …

[HTML][HTML] A need to increase von Willebrand disease awareness: vwdtest. com–A global initiative to help address this gap

FF Corrales-Medina, AB Federici, A Srivastava… - Blood reviews, 2023 - Elsevier
Von Willebrand disease (VWD) is an inherited bleeding disorder caused by quantitative or
qualitative deficiencies in von Willebrand factor (VWF). People with VWD may experience …

[HTML][HTML] Hemophilia

P Mehta, AKR Reddivari - 2019 - europepmc.org
Objectives: Identify the etiology of hemophilia. Review the evaluation of hemophilia. Outline
the treatment and management options available for hemophilia. Describe interprofessional …

Bleeding symptoms in patients diagnosed as type 3 von Willebrand disease: results from 3WINTERS‐IPS, an international and collaborative cross‐sectional study

A Tosetto, Z Badiee, MR Baghaipour… - … of Thrombosis and …, 2020 - Wiley Online Library
Abstract Background Type 3 von Willebrand's disease (VWD) patients present markedly
reduced levels of von Willebrand factor and factor VIII. Because of its rarity, the bleeding …

Von Willebrand Factor as a biomarker for liver disease–an update

A Elhence - Journal of Clinical and Experimental Hepatology, 2023 - Elsevier
The von Willebrand factor (vWF) is best known for its role in the hemostatic pathway, aiding
platelet adhesion and aggregation, as well as circulating along with coagulation factor VIII …

Preclinical evaluation of a semi‐automated and rapid commercial electrophoresis assay for von Willebrand factor multimers

M Pikta, G Zemtsovskaja, H Bautista… - Journal of clinical …, 2018 - Wiley Online Library
Background The von Willebrand factor (VWF) multimer test is required to correctly subtype
qualitative type 2 von Willebrand disease (VWD). The current VWF multimer assays are …

Enhanced local disorder in a clinically elusive von willebrand factor provokes high-affinity platelet clumping

A Tischer, VR Machha, JP Frontroth, MA Brehm… - Journal of molecular …, 2017 - Elsevier
Mutation of the cysteines forming the disulfide loop of the platelet GPIbα adhesive A1
domain of von Willebrand factor (VWF) causes quantitative VWF deficiencies in the blood …

Whole blood ristocetin-activated platelet impedance aggregometry (Multiplate) for the rapid detection of Von Willebrand disease

DE Schmidt, M Bruzelius, A Majeed… - Thrombosis and …, 2017 - thieme-connect.com
Von Willebrand disease (VWD) is the most common bleeding disorder, but no bedside tests
specific for Von Willebrand factor are available. The objective of this study was to evaluate …

Bleeding patterns in patients before and after diagnosis of von Willebrand disease: Analysis of a US medical claims database

JC Roberts, LM Malec, I Halari, SA Hale… - …, 2022 - Wiley Online Library
Abstract Introduction Von Willebrand disease (VWD) is the most common inherited bleeding
disorder. The bleeding phenotype is variable, and some individuals have persistent …

Heavy menstrual bleeding in adolescent girls

J Davila, EM Alderman - Pediatric annals, 2020 - journals.healio.com
Heavy menstrual bleeding (HMB) is a common complaint among adolescent girls. It reflects
an abnormal volume of blood loss during the menstrual cycle. Abnormal uterine bleeding …