Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings
Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …
What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review
R Gurung, DP Prata - Psychological medicine, 2015 - cambridge.org
The powerful genome-wide association studies (GWAS) revealed common mutations that
increase susceptibility for schizophrenia (SZ) and bipolar disorder (BD), but the vast majority …
increase susceptibility for schizophrenia (SZ) and bipolar disorder (BD), but the vast majority …
Emotion regulation and trait anxiety are predicted by the microstructure of fibers between amygdala and prefrontal cortex
AS Eden, J Schreiber, A Anwander… - Journal of …, 2015 - Soc Neuroscience
Diffusion tensor imaging revealed that trait anxiety predicts the microstructural properties of
a prespecified fiber tract between the amygdala and the perigenual anterior cingulate cortex …
a prespecified fiber tract between the amygdala and the perigenual anterior cingulate cortex …
The anterior limb of the internal capsule: Anatomy, function, and dysfunction
K Mithani, B Davison, Y Meng, N Lipsman - Behavioural brain research, 2020 - Elsevier
The last two decades have seen a re-emergence of neurosurgery for severe, refractory
psychiatric diseases, largely due to the advent of more precise and safe operative …
psychiatric diseases, largely due to the advent of more precise and safe operative …
[HTML][HTML] White matter microstructural abnormalities in bipolar disorder: A whole brain diffusion tensor imaging study
Background Bipolar disorder (BD) is a chronic mental illness characterized by severe
disruptions in mood and cognition. Diffusion tensor imaging (DTI) studies suggest that white …
disruptions in mood and cognition. Diffusion tensor imaging (DTI) studies suggest that white …
Polygenic risk and white matter integrity in individuals at high risk of mood disorder
Background Bipolar disorder (BD) and major depressive disorder (MDD) are highly heritable
and genetically overlapping conditions characterized by episodic elevation and/or …
and genetically overlapping conditions characterized by episodic elevation and/or …
Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder
Several genome-wide association studies for bipolar disorder (BD) have found a strong
association of the Ankyrin 3 (ANK3) gene. This association spans numerous linked single …
association of the Ankyrin 3 (ANK3) gene. This association spans numerous linked single …
Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin
Ankyrin-G is a scaffolding protein required for the formation of the axon initial segment in
neurons. Recent genome-wide association studies and whole-exome sequencing have …
neurons. Recent genome-wide association studies and whole-exome sequencing have …
Bipolar disorder: a neural network perspective on a disorder of emotion and motivation
Bipolar disorder (BD) is a severe, chronic disease with a heritability of 60–80%. BD is
frequently misdiagnosed due to phenomenological overlap with other psychopathologies …
frequently misdiagnosed due to phenomenological overlap with other psychopathologies …
White matter alterations in bipolar disorder: potential for drug discovery and development
E Marlinge, F Bellivier, J Houenou - Bipolar disorders, 2014 - Wiley Online Library
Objectives Brain white matter (WM) alterations have recently emerged as potentially relevant
in bipolar disorder. New techniques such as diffusion tensor imaging allow precise …
in bipolar disorder. New techniques such as diffusion tensor imaging allow precise …