Genetics of diabetes mellitus and diabetes complications
Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …
[HTML][HTML] Recent insights into mechanisms of β-cell lipo-and glucolipotoxicity in type 2 diabetes
The deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose
homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may …
homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may …
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
T Ge, MR Irvin, A Patki, V Srinivasasainagendra… - Genome Medicine, 2022 - Springer
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic
and environmental risk factors that disproportionately afflicts communities of color …
and environmental risk factors that disproportionately afflicts communities of color …
[HTML][HTML] Diabetes mellitus: The epidemic of the century
AT Kharroubi, HM Darwish - World journal of diabetes, 2015 - ncbi.nlm.nih.gov
The epidemic nature of diabetes mellitus in different regions is reviewed. The Middle East
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P< 2.2× 10− 7); of …
of diverse ancestry, identifying 40 coding variant association signals (P< 2.2× 10− 7); of …
Genetics of type 2 diabetes—pitfalls and possibilities
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …
genetic, epigenetic and environmental factors. While the major environmental factors, diet …
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological …
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …
Diversity and inclusion in genomic research: why the uneven progress?
AR Bentley, S Callier, CN Rotimi - Journal of community genetics, 2017 - Springer
Conducting genomic research in diverse populations has led to numerous advances in our
understanding of human history, biology, and health disparities, in addition to discoveries of …
understanding of human history, biology, and health disparities, in addition to discoveries of …
The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies
AT Amare, KO Schubert, M Klingler-Hoffmann… - Translational …, 2017 - nature.com
Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene
studies have identified genetic variants associated with cardiovascular diseases, metabolic …
studies have identified genetic variants associated with cardiovascular diseases, metabolic …