Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4, 5-dihydropyrazoles as anticancer agents with …

WM Eldehna, MA El Hassab, ZM Elsayed, T Al-Warhi… - Scientific reports, 2022 - nature.com
Currently, the humanity is in a fierce battle against various health-related challenges
especially those associated with human malignancies. This created the urge to develop …

GC/MS Analysis of Essential Oil and Enzyme Inhibitory Activities of Syzygium cumini (Pamposia) Grown in Egypt: Chemical Characterization and Molecular Docking …

HAS El-Nashar, WM Eldehna, ST Al-Rashood… - Molecules, 2021 - mdpi.com
Syzygium cumini (Pomposia) is a well-known aromatic plant belonging to the family
Myrtaceae, and has been reported for its various traditional and pharmacological potentials …

Identification of antiviral phytochemicals as a potential SARS-CoV-2 main protease (Mpro) inhibitor using docking and molecular dynamics simulations

CN Patel, SP Jani, DG Jaiswal, SP Kumar… - Scientific Reports, 2021 - nature.com
Abstract Novel SARS-CoV-2, an etiological factor of Coronavirus disease 2019 (COVID-19),
poses a great challenge to the public health care system. Among other druggable targets of …

Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease

MH ElNaggar, AA Elgazar, G Gamal… - Journal of enzyme …, 2023 - Taylor & Francis
SARS-CoV-2 pandemic in the end of 2019 led to profound consequences on global health
and economy. Till producing successful vaccination strategies, the healthcare sectors …

Isolation, structure elucidation and antimicrobial evaluation of natural pentacyclic triterpenoids and phytochemical investigation of different fractions of Ziziphus spina …

EN Ads, SI Hassan, S Rajendrasozhan, MH Hetta… - Molecules, 2022 - mdpi.com
Ziziphus spina-christi L.(ZSC-L) is a tree with thorny branches, belongs to the family
Rhamnaceae and grows in the sub-tropics. The purpose of this research is to isolate and …

Reaction mechanism–explored with the unified reaction valley approach

E Kraka, JJ Antonio, M Freindorf - Chemical Communications, 2023 - pubs.rsc.org
One of the ultimate goals of chemistry is to understand and manipulate chemical reactions,
which implies the ability to monitor the reaction and its underlying mechanism at an atomic …

Comparative metabolic study of the chloroform fraction of three Cystoseira species based on UPLC/ESI/MS analysis and biological activities

SH Aly, AM Elissawy, MA El Hassab… - Journal of Enzyme …, 2024 - Taylor & Francis
This study aims to investigate the phytoconstituents of the chloroform fraction of three
Cystoseira spp. namely C. myrica, C. trinodis, and C. tamariscifolia using UPLC/ESI/MS …

GC/MS Profiling of the Essential Oil and Lipophilic Extract of Moricandia sinaica Boiss. and Evaluation of Their Cytotoxic and Antioxidant Activities

SH Aly, NH Kandil, RM Hemdan, SS Kotb, SS Zaki… - Molecules, 2023 - mdpi.com
The genus Moricandia (Brassicaceae) comprises about eight species that were used in
traditional medicine. Moricandia sinaica is used to alleviate certain disorders such as …

GC-MS metabolites profiling of anethole-rich oils by different extraction techniques: antioxidant, cytotoxicity and in-silico enzymes inhibitory insights

DM El-Kersh, NM Mostafa, S Fayez… - Journal of Enzyme …, 2022 - Taylor & Francis
GC-MS profiling and metabolomics study of anise and star anise oils obtained by
hydrodistillation, n-hexane, and microwave-assisted extraction methods were conducted …