Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological
variables pertaining to age, presence of metastases, extent of resection, histological …

PURPOSE Proton radiotherapy (PRT) may lessen the neuropsychological risk traditionally
associated with cranial radiotherapy for the treatment of pediatric brain tumors by reducing …

Background Patients with incomplete surgical resection of medulloblastoma are
controversially regarded as having a marker of high-risk disease, which leads to patients …

Recent research has demonstrated that survivors of childhood cancer are at risk for a myriad
of late effects that affect physical and mental quality of life. We discuss the patterns and …

Background Compared with traditional photon radiotherapy, proton radiotherapy irradiates
less normal tissue and might improve health outcomes associated with photon radiotherapy …

The development of targeted anti-cancer therapies through the study of cancer genomes is
intended to increase survival rates and decrease treatment-related toxicity. We treated a …

We asked whether pharmacological stimulation of endogenous neural precursor cells
(NPCs) may promote cognitive recovery and brain repair, focusing on the drug metformin, in …

Current therapies for medulloblastoma were introduced primarily in the 1980s and consist of
predominantly cytotoxic, nontargeted approaches. Mortality from medulloblastoma remains …

Introduction Confusion has surrounded the description of post-operative mutism and
associated morbidity in pediatric patients with cerebellar tumors for years. The heterogeneity …