In heterocyclic chemistry, amidoximes are mostly known as precursors for the synthesis of 1,
2, 4-oxadiazoles. Indeed, most of the works related to the use of amidoximes in the synthesis …

Sirt2 is a target for the treatment of neurological, metabolic, and age-related diseases
including cancer. Here we report a series of Sirt2 inhibitors based on the 1, 2, 4-oxadiazole …

Two new classes of antitubercular agents, namely 5-alkylsulfanyl-1-(3, 5-dinitrophenyl)-1H-
tetrazoles and 2-alkylsulfanyl-5-(3, 5-dinitrophenyl)-1, 3, 4-oxadiazoles, and their structure …

Herein, we reported a general, convenient, and efficient synthesis of 3, 5-disubstituted-1, 2,
4-oxadiazoles via cyclodehydration of O-acylamidoximes in the superbase system …

An unprecedented protocol for the synthesis of 1, 2, 4-oxadiazoles from carbamates has
been developed by employing nitriles as both substrates and solvents. This one-pot …

Papain-like protease (PLpro) is a promising therapeutic target for its pivotal role in the life
cycle of SARS-CoV-2. A series of 1, 2, 4-oxadiazole derivatives was designed and …

A one-pot method for the synthesis of biphenylcarboxylic acids containing 1, 2, 4-oxadiazole
ring in the NaOH–DMSO system was developed. The results of in vitro experiments showed …

The study of high-energy materials based on polynitrogen-and nitrogen-oxygen-containing
heterocycles is one of the most important and relevant modern interdisciplinary research …

2, 3-dihydro-5, 6, 7, 8-tetranitro-1, 4-benzodioxine (TNBD), molecular formula=
C8H4N4O10, is a completely nitrated aromatic ring 1, 4-benzodioxane derivative. The …

Melt-cast explosives are the most widely used energetic materials in military composite
explosives, researchers have been unremittingly exploring high-energy and insensitive melt …