Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity

B Shuch, A Amin, AJ Armstrong, JN Eble, V Ficarra… - European urology, 2015 - Elsevier
Context Once believed to represent a uniform malignant phenotype, renal cell carcinoma
(RCC) is now viewed as a diverse group of cancers that arise from the nephron. Objective …

[HTML][HTML] B7-H3 role in the immune landscape of cancer

JR Castellanos, IJ Purvis, CM Labak… - American journal of …, 2017 - ncbi.nlm.nih.gov
The field of immunotherapy is a continually expanding niche in cancer biology research. In
the last two decades, there has been significant progress in identifying better targets and …

The somatic genomic landscape of chromophobe renal cell carcinoma

CF Davis, CJ Ricketts, M Wang, L Yang, AD Cherniack… - Cancer cell, 2014 - cell.com
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell
carcinomas (ChRCCs) on the basis of multidimensional and comprehensive …

The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters

B Delahunt, JC Cheville, G Martignoni… - The American journal …, 2013 - journals.lww.com
Abstract The International Society of Urological Pathology 2012 Consensus Conference
made recommendations regarding classification, prognostic factors, staging, and …

Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial

B Escudier, T Eisen, WM Stadler, C Szczylik… - Journal of clinical …, 2009 - ascopubs.org
Purpose Mature survival data and evaluation of vascular endothelial growth factor (VEGF)
as a prognostic biomarker from the Treatment Approaches in Renal Cancer Global …

An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the …

I Frank, ML Blute, JC Cheville, CM Lohse… - The Journal of …, 2002 - auajournals.org
Purpose: Currently outcome prediction in renal cell carcinoma is largely based on
pathological stage and tumor grade. We developed an outcome prediction model for …

Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma

JC Cheville, CM Lohse, H Zincke… - The American journal …, 2003 - journals.lww.com
Our objective was to compare cancer-specific survival and to examine associations with
outcome among the histologic subtypes of renal cell carcinoma (RCC). We studied 2385 …

Solid renal tumors: an analysis of pathological features related to tumor size

I Frank, ML Blute, JC Cheville, CM Lohse… - The Journal of …, 2003 - auajournals.org
Purpose: We examined the relationship between tumor size and malignancy among solid
renal tumors, and the relationship between tumor size and RCC subtype within tumors with …

Genomic profiling in renal cell carcinoma

N Dizman, EJ Philip, SK Pal - Nature reviews nephrology, 2020 - nature.com
The treatment landscape of metastatic renal cell carcinoma (RCC) has been revolutionized
over the past two decades, bringing forth an era in which more than a dozen therapeutic …

WHO/ISUP classification, grading and pathological staging of renal cell carcinoma: standards and controversies

AY Warren, D Harrison - World journal of urology, 2018 - Springer
Purpose Pathological parameters assessed on biopsies and resection specimens have a
pivotal role in the diagnosis, prognosis and management of patients with renal cell …