[HTML][HTML] C. elegans as a model for membrane traffic
K Sato, A Norris, M Sato, BD Grant - … the online review of C. elegans …, 2018 - ncbi.nlm.nih.gov
The counterbalancing action of the endocytosis and secretory pathways maintains a
dynamic equilibrium that regulates the composition of the plasma membrane, allowing it to …
dynamic equilibrium that regulates the composition of the plasma membrane, allowing it to …
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles
Genetic conservation allows ancient features of fat storage endocrine pathways to be
explored in C. elegans. Multiple studies have used Nile red or BODIPY-labeled fatty acids to …
explored in C. elegans. Multiple studies have used Nile red or BODIPY-labeled fatty acids to …
Lysosome-related organelles promote stress and immune responses in C. elegans
Lysosome-related organelles (LROs) play diverse roles and their dysfunction causes
immunodeficiency. However, their primordial functions remain unclear. Here, we report that …
immunodeficiency. However, their primordial functions remain unclear. Here, we report that …
Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans
Zinc is an essential trace element involved in many biological processes and human
diseases. Because zinc deficiency and excess are deleterious, animals require homeostatic …
diseases. Because zinc deficiency and excess are deleterious, animals require homeostatic …
Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network
Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene
expression at a systems level. GRNs that relate to metazoan development have been …
expression at a systems level. GRNs that relate to metazoan development have been …
A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans
Regulation of animal development in response to nutritional cues is an intensely studied
problem related to disease and aging. While extensive studies indicated roles of the Target …
problem related to disease and aging. While extensive studies indicated roles of the Target …
Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans
Statins are compounds prescribed to lower blood cholesterol in millions of patients
worldwide. They act by inhibiting HMG-CoA reductase, the rate-limiting enzyme in the …
worldwide. They act by inhibiting HMG-CoA reductase, the rate-limiting enzyme in the …
Intracellular trafficking pathways in silver nanoparticle uptake and toxicity in Caenorhabditis elegans
We used the nematode Caenorhabditis elegans to study the roles of endocytosis and
lysosomal function in uptake and subsequent toxicity of silver nanoparticles (AgNP) in vivo …
lysosomal function in uptake and subsequent toxicity of silver nanoparticles (AgNP) in vivo …
Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis elegans
The nematode C. elegans has emerged as an important model for the study of conserved
genetic pathways regulating fat metabolism as it relates to human obesity and its associated …
genetic pathways regulating fat metabolism as it relates to human obesity and its associated …
Loss of the apical V-ATPase a-subunit VHA-6 prevents acidification of the intestinal lumen during a rhythmic behavior in C. elegans
In Caenorhabditis elegans, oscillations of intestinal pH contribute to the rhythmic defecation
behavior, but the acid-base transport mechanisms that facilitate proton movement are not …
behavior, but the acid-base transport mechanisms that facilitate proton movement are not …