Analytical quantitation of compounds in tissue has become a more prevalent addition to
biological sample analysis in recent times. This increase will most certainly continue to bring …

In order to measure the levels of serotonin (5-hydroxyltryptamine, 5-HT), dopamine (DA), 3,
4-hydroxyphenylacetic acid (DOPAC), 3-methoxytyramine (3-MT) and homovanillic acid …

Background: In recent years, the significance of cytochrome P450 enzymes (CYPs) has
expanded beyond their role in the liver. Factors such as genetics, environmental toxins, drug …

Parkinson's disease (PD) is the second most common neurodegenerative disorder
affecting~ 1% of the population older than 60 years. The administration of the proneurotoxin …

Hypothalamic tuberoinfundibular dopamine (TIDA) neurons remain unaffected in Parkinson
disease (PD) while there is significant degeneration of midbrain nigrostriatal dopamine …

Dopaminergic (DAergic) neurons of the midbrain ventral tegmental area (VTA) are known to
regulate the hypothalamic‐pituitary‐adrenal (HPA) axis but have no direct projections to the …

Metabolic enzymes are involved in the activation/deactivation of the 1‐methyl‐4‐phenyl‐1,
2, 3, 6‐tetrahydropyiridine (MPTP) neurotoxin and its naturally occurring analogs 2 …

Aim The present study investigated the effects of dorsal hypothalamic dopamine (dh‐DA)
neurons on activation of hypothalamic‐pituitary‐adrenal (HPA) axis in adult male mice …

Quantitative measurement of drug levels in tissue by LC‐MS/MS is widely used due to the
sensitivity, selectivity, and relative simplicity of the method. However, to achieve …

Abstract Motor dysfunctions of Parkinson Disease (PD) are due to the progressive loss of
midbrain nigrostriatal dopamine (NSDA) neurons. Evidence suggests a role for cannabinoid …