Importance of the pig as a human biomedical model
JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …
Engineering microneedle patches for improved penetration: analysis, skin models and factors affecting needle insertion
P Makvandi, M Kirkby, ARJ Hutton, M Shabani… - Nano-Micro Letters, 2021 - Springer
Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety
of active compounds into the skin. To serve as a substitute for common hypodermic needles …
of active compounds into the skin. To serve as a substitute for common hypodermic needles …
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
Y You, Y Tian, Z Yang, J Shi, KJ Kwak, Y Tong… - Nature biomedical …, 2023 - nature.com
The success of messenger RNA therapeutics largely depends on the availability of delivery
systems that enable the safe, effective and stable translation of genetic material into …
systems that enable the safe, effective and stable translation of genetic material into …
Topical drug delivery: History, percutaneous absorption, and product development
Topical products, widely used to manage skin conditions, have evolved from simple potions
to sophisticated delivery systems. Their development has been facilitated by advances in …
to sophisticated delivery systems. Their development has been facilitated by advances in …
Cryomicroneedles for transdermal cell delivery
Cell therapies for the treatment of skin disorders could benefit from simple, safe and efficient
technology for the transdermal delivery of therapeutic cells. Conventional cell delivery by …
technology for the transdermal delivery of therapeutic cells. Conventional cell delivery by …
Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability issues, basic considerations and applications
The use of nanoemulsion in augmenting dermal and transdermal effectiveness of drugs has
now well established. The development of nanoemulsion based semisolid dosage forms is …
now well established. The development of nanoemulsion based semisolid dosage forms is …
Promising natural products in new drug design, development, and therapy for skin disorders: An overview of scientific evidence and understanding their mechanism of …
The skin is the largest organ in the human body, composed of the epidermis and the dermis.
It provides protection and acts as a barrier against external menaces like allergens …
It provides protection and acts as a barrier against external menaces like allergens …
[HTML][HTML] Alternatives to biological skin in permeation studies: Current trends and possibilities
The transdermal route of drugs has received increased attention in recent years due to
numerous advantages over the oral and injectable routes, such as avoidance of the hepatic …
numerous advantages over the oral and injectable routes, such as avoidance of the hepatic …
Methods for evaluating penetration of drug into the skin: A review
S Supe, P Takudage - Skin research and technology, 2021 - Wiley Online Library
Background Skin being the largest organ of the human body plays a very important role in
the permeation and penetration of the drug. In addition, the transdermal drug delivery …
the permeation and penetration of the drug. In addition, the transdermal drug delivery …
Mechanisms of sampling interstitial fluid from skin using a microneedle patch
PP Samant, MR Prausnitz - Proceedings of the National …, 2018 - National Acad Sciences
Although interstitial fluid (ISF) contains biomarkers of physiological significance and medical
interest, sampling of ISF for clinical applications has made limited impact due to a lack of …
interest, sampling of ISF for clinical applications has made limited impact due to a lack of …