Importance of the pig as a human biomedical model

JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

Engineering microneedle patches for improved penetration: analysis, skin models and factors affecting needle insertion

P Makvandi, M Kirkby, ARJ Hutton, M Shabani… - Nano-Micro Letters, 2021 - Springer
Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety
of active compounds into the skin. To serve as a substitute for common hypodermic needles …

Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

Y You, Y Tian, Z Yang, J Shi, KJ Kwak, Y Tong… - Nature biomedical …, 2023 - nature.com
The success of messenger RNA therapeutics largely depends on the availability of delivery
systems that enable the safe, effective and stable translation of genetic material into …

Topical drug delivery: History, percutaneous absorption, and product development

MS Roberts, HS Cheruvu, SE Mangion… - Advanced drug delivery …, 2021 - Elsevier
Topical products, widely used to manage skin conditions, have evolved from simple potions
to sophisticated delivery systems. Their development has been facilitated by advances in …

Cryomicroneedles for transdermal cell delivery

H Chang, SWT Chew, M Zheng, DCS Lio… - Nature Biomedical …, 2021 - nature.com
Cell therapies for the treatment of skin disorders could benefit from simple, safe and efficient
technology for the transdermal delivery of therapeutic cells. Conventional cell delivery by …

Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability issues, basic considerations and applications

VK Rai, N Mishra, KS Yadav, NP Yadav - Journal of controlled release, 2018 - Elsevier
The use of nanoemulsion in augmenting dermal and transdermal effectiveness of drugs has
now well established. The development of nanoemulsion based semisolid dosage forms is …

Promising natural products in new drug design, development, and therapy for skin disorders: An overview of scientific evidence and understanding their mechanism of …

NA Mohd Zaid, M Sekar, SR Bonam… - Drug design …, 2023 - Taylor & Francis
The skin is the largest organ in the human body, composed of the epidermis and the dermis.
It provides protection and acts as a barrier against external menaces like allergens …

[HTML][HTML] Alternatives to biological skin in permeation studies: Current trends and possibilities

R Neupane, SHS Boddu, J Renukuntla, RJ Babu… - Pharmaceutics, 2020 - mdpi.com
The transdermal route of drugs has received increased attention in recent years due to
numerous advantages over the oral and injectable routes, such as avoidance of the hepatic …

Methods for evaluating penetration of drug into the skin: A review

S Supe, P Takudage - Skin research and technology, 2021 - Wiley Online Library
Background Skin being the largest organ of the human body plays a very important role in
the permeation and penetration of the drug. In addition, the transdermal drug delivery …

Mechanisms of sampling interstitial fluid from skin using a microneedle patch

PP Samant, MR Prausnitz - Proceedings of the National …, 2018 - National Acad Sciences
Although interstitial fluid (ISF) contains biomarkers of physiological significance and medical
interest, sampling of ISF for clinical applications has made limited impact due to a lack of …