Genome-wide mapping and analysis of chromosome architecture
Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …
An overview of genome organization and how we got there: from FISH to Hi-C
J Fraser, I Williamson, WA Bickmore… - … and Molecular Biology …, 2015 - Am Soc Microbiol
In humans, nearly two meters of genomic material must be folded to fit inside each
micrometer-scale cell nucleus while remaining accessible for gene transcription, DNA …
micrometer-scale cell nucleus while remaining accessible for gene transcription, DNA …
Single-cell Hi-C for genome-wide detection of chromatin interactions that occur simultaneously in a single cell
Hi-C is a powerful method that provides pairwise information on genomic regions in spatial
proximity in the nucleus. Hi-C requires millions of cells as input and, as genome …
proximity in the nucleus. Hi-C requires millions of cells as input and, as genome …
Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions
Chromosome conformation capture (3C) technology is a powerful and increasingly popular
tool for analyzing the spatial organization of genomes. Several 3C variants have been …
tool for analyzing the spatial organization of genomes. Several 3C variants have been …
Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus
Epstein-Barr virus (EBV) genomes persist in latently infected cells as extrachromosomal
episomes that attach to host chromosomes through the tethering functions of EBNA1, a viral …
episomes that attach to host chromosomes through the tethering functions of EBNA1, a viral …
Chromatin states and nuclear organization in development—a view from the nuclear lamina
The spatial distribution of chromatin domains in interphase nuclei changes dramatically
during development in multicellular organisms. A crucial question is whether nuclear …
during development in multicellular organisms. A crucial question is whether nuclear …
ENdb: a manually curated database of experimentally supported enhancers for human and mouse
X Bai, S Shi, B Ai, Y Jiang, Y Liu, X Han… - Nucleic acids …, 2020 - academic.oup.com
Enhancers are a class of cis-regulatory elements that can increase gene transcription by
forming loops in intergenic regions, introns and exons. Enhancers, as well as their …
forming loops in intergenic regions, introns and exons. Enhancers, as well as their …
An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice
JPL Castro, MN Yancoskie, M Marchini, S Belohlavy… - elife, 2019 - elifesciences.org
Evolutionary studies are often limited by missing data that are critical to understanding the
history of selection. Selection experiments, which reproduce rapid evolution under …
history of selection. Selection experiments, which reproduce rapid evolution under …
Targeted Chromatin Capture (T2C): a novel high resolution high throughput method to detect genomic interactions and regulatory elements
Background Significant efforts have recently been put into the investigation of the spatial
organization and the chromatin-interaction networks of genomes. Chromosome …
organization and the chromatin-interaction networks of genomes. Chromosome …
Insights into early animal evolution from the genome of the xenacoelomorph worm Xenoturbella bocki
PH Schiffer, P Natsidis, DJ Leite, HE Robertson… - Elife, 2024 - elifesciences.org
The evolutionary origins of Bilateria remain enigmatic. One of the more enduring proposals
highlights similarities between a cnidarian-like planula larva and simple acoel-like …
highlights similarities between a cnidarian-like planula larva and simple acoel-like …