Liver is deeply involved in the metabolism of proteins, hormones, enzymes, cytokines, as
well as in sex hormones catabolism. Gonadal function requires a normal liver function, and it …

Cyclosporine, the prototype calcineurin inhibitor, transformed immunosuppressant regimens
and practices post-organ transplantation. Therapeutic uses of cyclosporine branched out to …

In addition to insulin sensitization, the thiazolidenedione drug pioglitazone exhibits
favorable circulatory effects. Here, we hypothesized that pioglitazone protects against the …

Background and Purpose Cyclosporine (CSA) and non‐steroidal anti‐inflammatory drugs
(NSAIDs) are co‐prescribed for some arthritic conditions. We tested the hypothesis that this …

Arterial hypertension is a considerable side effect that accompanies the clinical use of
immunosuppressant drugs such as cyclosporine (CSA). In addition to promoting graft …

Cyclosporine A (CSA) is a widely used immunosuppressant drug known to commonly cause
cardio and nephrotoxicity. A study looking at the sex specificity of the cardiotoxicity of CSA …

The immunosuppressant drug cyclosporine (CSA) is used with nonsteroidal
antiinflammatory drugs (NSAIDs) in arthritic conditions. In this study, we investigated …

Objective The current study investigated for the first time the possible beneficial effect of
zileuton, a selective 5-lipoxygenase inhibitor (5-LOX), against cisplatin-induced acute renal …

Aim/hypothesis: In utero exposure to maternal diabetes increases the risk of developing
hypertension and cardiovascular disorders during adulthood. We have previously shown …

Endothelin (ET) signaling provokes nephrotoxicity induced by the immunosuppressant drug
cyclosporine A (CSA). We tested the hypotheses that (i): celecoxib, a selective …