Pancreatic β-cells are responsible for the synthesis and exocytosis of insulin in response to
an increase in circulating glucose. Insulin secretion occurs in a pulsatile manner, with …

Insulin is secreted in pulses from pancreatic beta‐cells, and these oscillations maintain
fasting plasma glucose levels within a narrow normal range. Within islets, beta‐cells exhibit …

Background Diabetes is a heterogeneous and multifactorial disease. However, glycemia
and glycated hemoglobin have been the focus of diabetes diagnosis and management for …

Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been
attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show …

Endogenous insulin secretion is a key regulator of postprandial hepatic glucose metabolism,
but this process is dysregulated in diabetes. Subcutaneous insulin delivery alters normal …

Diabetes is a heterogeneous and multifactorial disease. However, glycemia and glycated
hemoglobin have been the focus of diabetes diagnosis and management for the last …

Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by a dysregulation of
glucose homeostasis. The pathophysiology of this disease is complex characterized by a …