Multisystem physiological perspective of human frailty and its modulation by physical activity

JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Association between Frailty and Mortality, Falls, and Hospitalization among Patients with Hypertension: A Systematic Review and Meta‐Analysis

K Hu, Q Zhou, Y Jiang, Z Shang, F Mei… - BioMed research …, 2021 - Wiley Online Library
Objective. Chronological age alone does not adequately reflect the difference in health
status of a patient with hypertension. Frailty is closely associated with biological age, and its …

Association of white matter hyperintensity markers on MRI and long-term risk of mortality and ischemic stroke: the SMART-MR study

R Ghaznawi, MI Geerlings, M Jaarsma-Coes… - Neurology, 2021 - AAN Enterprises
Objective To determine whether white matter hyperintensity (WMH) markers on MRI are
associated with long-term risk of mortality and ischemic stroke. Methods We included …

[HTML][HTML] Functional brain network and trail making test changes following major surgery and postoperative delirium: a prospective, multicentre, observational cohort …

FL Ditzel, SJT van Montfort, LM Vernooij… - British Journal of …, 2023 - Elsevier
Background Delirium is a frequent complication after surgery in older adults and is
associated with an increased risk of long-term cognitive impairment and dementia …

Higher hospital frailty risk score is associated with increased risk of stroke: observational and genetic analyses

D Renedo, JN Acosta, AB Koo, C Rivier, N Sujijantarat… - Stroke, 2023 - Am Heart Assoc
Background: Frailty is a prevalent state associated with several aging-related traits and
conditions. The relationship between frailty and stroke remains understudied. Here we aim …

Parkinsonism and cerebrovascular disease

M Narasimhan, R Schwartz, G Halliday - Journal of the Neurological …, 2022 - Elsevier
The relationship between cerebrovascular disease and parkinsonism is commonly seen in
everyday clinical practice but remains ill-defined and under-recognised with little guidance …

Microstructural neuroimaging of frailty in cognitively normal older adults

Q Tian, OA Williams, BA Landman, SM Resnick… - Frontiers in …, 2020 - frontiersin.org
Physical frailty is an age-related clinical syndrome that is associated with multiple adverse
health outcomes, including cognitive impairment and dementia. Recent studies have shown …

[HTML][HTML] Frailty and dementia risks in asymptomatic cerebral small vessel disease: a longitudinal cohort study

CP Chung, WJ Lee, KH Chou, PL Lee, LN Peng… - Archives of Gerontology …, 2022 - Elsevier
Objectives Frailty has been shown to predict adverse outcomes in several diseases. We
aimed to evaluate the associations between frailty profiles, both severity and subtype, and …

Brain structural alterations and clinical features of cognitive frailty in Japanese community-dwelling older adults: the Arao study (JPSC-AD)

K Yoshiura, R Fukuhara, T Ishikawa, N Tsunoda… - Scientific Reports, 2022 - nature.com
Cognitive frailty (CF) is a clinical condition defined by the presence of both mild cognitive
impairment (MCI) and physical frailty (PF). Elderly with CF are at greater risk of dementia …

Biological and neuroimaging markers as predictors of 5-year incident frailty in older adults: a secondary analysis of the MAPT study

WH Lu, P de Souto Barreto, Y Rolland… - The Journals of …, 2021 - academic.oup.com
Background This study aims to investigate the predictive value of biological and
neuroimaging markers to determine incident frailty among older people for a period of 5 …