Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional
overdose of acetaminophen (APAP) has affected patients for decades, and involves the …

There are currently more than 1000 prescription medications available for use in the United
States and more than 100,000 over-the-counter herbal and dietary supplements (HDS) …

Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug
reaction that should be considered in patients who develop laboratory criteria for liver injury …

Current blood biomarkers are suboptimal in detecting drug‐induced liver injury (DILI) and
predicting its outcome. We sought to characterize the natural variabilty and performance …

Drug-induced liver injury (DILI) is one among the common adverse drug reactions and the
leading causes of drug development attritions, black box warnings, and post-marketing …

The hepatotoxicity of drugs is the main cause of drug withdrawal from the pharmaceutical
market and interruption of the development of new molecules. Biomarkers are useful in …

The aims of this study were to determine the role of cell death in patients with cirrhosis and
acute decompensation (AD) and acute on chronic liver failure (ACLF) using plasma‐based …

Numerous publications contributed to the expanding knowledge base about drug-induced
liver injury (DILI) in 2015. New findings from the US Drug Induced Liver Injury Network …

The liver is responsible for extremely important functions in the human body. In the liver's
structure, we distinguish between connective tissue (stroma) and parenchyma, the latter of …