Tumour-targeting bacteria engineered to fight cancer

S Zhou, C Gravekamp, D Bermudes, K Liu - Nature Reviews Cancer, 2018 - nature.com
Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …

[HTML][HTML] Preclinical mouse cancer models: a maze of opportunities and challenges

CP Day, G Merlino, T Van Dyke - Cell, 2015 - cell.com
Significant advances have been made in developing novel therapeutics for cancer
treatment, and targeted therapies have revolutionized the treatment of some cancers …

Preclinical mouse solid tumour models: status quo, challenges and perspectives

N Gengenbacher, M Singhal, HG Augustin - Nature Reviews Cancer, 2017 - nature.com
Oncology research in humans is limited to analytical and observational studies for obvious
ethical reasons, with therapy-focused clinical trials being the one exception to this rule …

[HTML][HTML] Classical mathematical models for description and prediction of experimental tumor growth

S Benzekry, C Lamont, A Beheshti… - PLoS computational …, 2014 - journals.plos.org
Despite internal complexity, tumor growth kinetics follow relatively simple laws that can be
expressed as mathematical models. To explore this further, quantitative analysis of the most …

Patient-derived tumor xenografts: transforming clinical samples into mouse models

D Siolas, GJ Hannon - Cancer research, 2013 - AACR
Tumor graft models (also known as patient-derived xenografts or PDX) are based on the
transfer of primary tumors directly from the patient into an immunodeficient mouse. Because …

AACR centennial series: the biology of cancer metastasis: historical perspective

JE Talmadge, IJ Fidler - Cancer research, 2010 - AACR
Metastasis resistant to therapy is the major cause of death from cancer. Despite almost 200
years of study, the process of tumor metastasis remains controversial. Stephen Paget initially …

The role of adiponectin in cancer: a review of current evidence

M Dalamaga, KN Diakopoulos… - Endocrine …, 2012 - academic.oup.com
Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

[HTML][HTML] Mouse models of colorectal cancer: Past, present and future perspectives

F Bürtin, CS Mullins, M Linnebacher - World journal of …, 2020 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

Nanoparticle characterization: state of the art, challenges, and emerging technologies

EJ Cho, H Holback, KC Liu… - Molecular …, 2013 - ACS Publications
Nanoparticles have received enormous attention as a promising tool to enhance target-
specific drug delivery and diagnosis. Various in vitro and in vivo techniques are used to …

Mediating passive tumor accumulation through particle size, tumor type, and location

JL Perry, KG Reuter, JC Luft, CV Pecot, W Zamboni… - Nano …, 2017 - ACS Publications
As the enhanced permeation and retention (EPR) effect continues to be a controversial topic
in nanomedicine, we sought to examine EPR as a function of nanoparticle size, tumor …