Considered by some to be among the simpler forms of life, viruses represent highly evolved
natural vectors for the transfer of foreign genetic information into cells. This attribute has led …

Recent endeavors in the development of adenovirus as a gene vector have focused on the
modification of virus tropism, the accomodation of larger genes, and the increase in stability …

Vectors based on human adenovirus (Ad) and adeno-associated virus (AAV) are being
evaluated for human gene therapy. The response of the host to the vector, in terms of …

CV706 is a prostate-specific antigen (PSA)-selective, replication-competent adenovirus that
has been shown to selectively kill human prostate cancer xenografts in preclinical models …

A phase I clinical trial was conducted to determine the clinical safety of Telomelysin, a
human telomerase reverse transcriptase (hTERT) promoter driven modified oncolytic …

One of the major limitations of the use of adenoviruses as gene therapy vectors is the
existence of preformed immunity in various populations. Recent studies have linked failure …

Systemic application of first-generation adenovirus induces pathogenic effects in the liver.
To begin unraveling the mechanisms underlying early liver toxicity after adenovirus infusion …

ADENOVIRUSES WERE FIRST DISCOVERED half a century ago by Rowe and colleagues,
who were trying to culture adenoid tissue in the laboratory (Rowe et al., 1953). Since that …

Adenovirus (Ad)-based vectors have great potential for use in the gene therapy of multiple
diseases, both genetic and nongenetic. While capable of transducing both dividing and …

Although genetically engineered adenoviruses hold promise for the treatment of cancer,
clinical trial reports have utilized intratumoral injection to date. To determine the feasibility of …