Structure and mechanics of dynein motors
Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …
Tau toxicity in neurodegeneration
SY Liang, ZT Wang, L Tan, JT Yu - Molecular Neurobiology, 2022 - Springer
Tau is a microtubule-associated protein widely distributed in the central nervous system
(CNS). The main function of tau is to promote the assembly of microtubules and stabilize …
(CNS). The main function of tau is to promote the assembly of microtubules and stabilize …
Programmable molecular transport achieved by engineering protein motors to move on DNA nanotubes
R Ibusuki, T Morishita, A Furuta, S Nakayama… - Science, 2022 - science.org
Intracellular transport is the basis of microscale logistics within cells and is powered by
biomolecular motors. Mimicking transport for in vitro applications has been widely studied; …
biomolecular motors. Mimicking transport for in vitro applications has been widely studied; …
In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems
Parasites of the phylum Apicomplexa cause important diseases including malaria,
cryptosporidiosis and toxoplasmosis. These intracellular pathogens inject the contents of an …
cryptosporidiosis and toxoplasmosis. These intracellular pathogens inject the contents of an …
Lis1 activates dynein motility by modulating its pairing with dynactin
Abstract Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport
towards the minus-ends of microtubules. It remains unclear whether Lis1 serves as an …
towards the minus-ends of microtubules. It remains unclear whether Lis1 serves as an …
Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity
Dynein is a microtubule motor that transports many different cargos in various cell types and
contexts. How dynein is regulated to perform these activities with spatial and temporal …
contexts. How dynein is regulated to perform these activities with spatial and temporal …
Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin
Cytoplasmic dynein is an ATP-driven motor that transports intracellular cargos along
microtubules. Dynein adopts an inactive conformation when not attached to a cargo, and …
microtubules. Dynein adopts an inactive conformation when not attached to a cargo, and …
Activation and regulation of cytoplasmic dynein
Cytoplasmic dynein is an AAA+ motor that drives the transport of many intracellular cargoes
towards the minus end of microtubules (MTs). Previous in vitro studies characterized …
towards the minus end of microtubules (MTs). Previous in vitro studies characterized …
A cryo-ET survey of microtubules and intracellular compartments in mammalian axons
The neuronal axon is packed with cytoskeletal filaments, membranes, and organelles, many
of which move between the cell body and axon tip. Here, we used cryo-electron tomography …
of which move between the cell body and axon tip. Here, we used cryo-electron tomography …
Sterically driven current reversal in a molecular motor model
Simulations can help unravel the complicated ways in which molecular structure determines
function. Here, we use molecular simulations to show how slight alterations of a molecular …
function. Here, we use molecular simulations to show how slight alterations of a molecular …