Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Calcium (Ca2+) plays a pivotal role in almost all cellular processes and ensures the
functionality of an organism. In skeletal muscle fibers, Ca2+ is critically involved in the …

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a
heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac …

The sarcoplasmic reticulum (SR) provides feedback control required to balance the
processes of calcium storage, release, and reuptake in skeletal muscle. This balance is …

Of the three mammalian members belonging to the sarco (endo) plasmic reticulum Ca2+
ATPase (SERCA) family, SERCA2 is evolutionary the oldest and shows the most wide tissue …

Wooden Breast Disease (WBD), a myopathy in commercial broiler chickens characterized
by abnormally firm consistency of the pectoral muscle, impacts the poultry industry …

Abstract Exercise-induced rhabdomyolysis (exRML), a pathophysiological condition of
skeletal muscle cell damage that may cause acute renal failure and in some cases death …

Objective NAD+ is a co-factor and substrate for enzymes maintaining energy homeostasis.
Nicotinamide phosphoribosyltransferase (NAMPT) controls NAD+ synthesis, and in skeletal …

The sarcoplasmic reticulum of skeletal muscle cells is a highly ordered structure consisting
of an intricate network of tubules and cisternae specialized for regulating Ca2+ homeostasis …

Abstract Calpain 1 and 2 (CPN1/2) are calcium-dependent cysteine proteases that exist in
cytosol and mitochondria. Pharmacologic inhibition of CPN1/2 decreases cardiac injury …