Over the last years computer modelling and simulation has emerged as an effective tool to
support the total product life cycle of cardiovascular devices, particularly in the device …

The manufacture of fibrous scaffolds with tailored micrometric features and anatomically
relevant three-dimensional (3D) geometries for soft tissue engineering applications remains …

The aortic root is an important anatomical structure positioned at the center of the heart,
making it critical to the functioning of the major cardiac chambers. Deep knowledge of the …

Transcatheter valve replacement indication is currently being extended to younger and
lower-risk patients. However, transcatheter prostheses are still based on glutaraldehyde …

Objective The optimal conduit for valve-sparing aortic root replacement is still debated, with
several conduit variations available, ranging from straight tubular grafts to Valsalva grafts …

Background: Many graft configurations are clinically used for valve-sparing aortic root
replacement, some specifically focused on recapitulating neosinus geometry. However, the …

In this paper, we describe a three-dimensional simulation of the fluid–structure interaction
(FSI) of the aortic valve using a direct-forcing immersed-boundary method. The geometry of …

Purpose The understanding of the optimum function of the healthy aortic valve is essential in
interpreting the effect of pathologies in the region, and in devising effective treatments to …

Objectives This study applied advanced 4-dimensional flow magnetic resonance imaging
processing to assess differences in aortic flow dynamics after valve sparing root …

Tissue-engineered heart valves with self-repair and regeneration properties may overcome
the problem of long-term degeneration of currently used artificial prostheses. The aim of this …