A brief history of protein sorting prediction
Ever since the signal hypothesis was proposed in 1971, the exact nature of signal peptides
has been a focus point of research. The prediction of signal peptides and protein subcellular …
has been a focus point of research. The prediction of signal peptides and protein subcellular …
Genome-scale metabolic modeling enables in-depth understanding of big data
Genome-scale metabolic models (GEMs) enable the mathematical simulation of the
metabolism of archaea, bacteria, and eukaryotic organisms. GEMs quantitatively define a …
metabolism of archaea, bacteria, and eukaryotic organisms. GEMs quantitatively define a …
PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes
Motivation: PSORTb has remained the most precise bacterial protein subcellular localization
(SCL) predictor since it was first made available in 2003. However, the recall needs to be …
(SCL) predictor since it was first made available in 2003. However, the recall needs to be …
A protocol for generating a high-quality genome-scale metabolic reconstruction
I Thiele, BØ Palsson - Nature protocols, 2010 - nature.com
Network reconstructions are a common denominator in systems biology. Bottom–up
metabolic network reconstructions have been developed over the last 10 years. These …
metabolic network reconstructions have been developed over the last 10 years. These …
Locating proteins in the cell using TargetP, SignalP and related tools
Determining the subcellular localization of a protein is an important first step toward
understanding its function. Here, we describe the properties of three well-known N-terminal …
understanding its function. Here, we describe the properties of three well-known N-terminal …
Prediction of protein subcellular localization
Because the protein's function is usually related to its subcellular localization, the ability to
predict subcellular localization directly from protein sequences will be useful for inferring …
predict subcellular localization directly from protein sequences will be useful for inferring …
[HTML][HTML] pLoc-mEuk: Predict subcellular localization of multi-label eukaryotic proteins by extracting the key GO information into general PseAAC
X Cheng, X Xiao, KC Chou - Genomics, 2018 - Elsevier
Many efforts have been made in predicting the subcellular localization of eukaryotic
proteins, but most of the existing methods have the following two limitations:(1) their …
proteins, but most of the existing methods have the following two limitations:(1) their …
Pseudomonas Genome Database: improved comparative analysis and population genomics capability for Pseudomonas genomes
GL Winsor, DKW Lam, L Fleming, R Lo… - Nucleic acids …, 2010 - academic.oup.com
Pseudomonas is a metabolically-diverse genus of bacteria known for its flexibility and
leading free living to pathogenic lifestyles in a wide range of hosts. The Pseudomonas …
leading free living to pathogenic lifestyles in a wide range of hosts. The Pseudomonas …
Some remarks on predicting multi-label attributes in molecular biosystems
KC Chou - Molecular Biosystems, 2013 - pubs.rsc.org
Many molecular biosystems and biomedical systems belong to the multi-label systems in
which each of their constituent molecules possesses one or more than one function or …
which each of their constituent molecules possesses one or more than one function or …
NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens
For over 30 years a phospholipase C enzyme called alpha-toxin was thought to be the key
virulence factor in necrotic enteritis caused by Clostridium perfringens. However, using a …
virulence factor in necrotic enteritis caused by Clostridium perfringens. However, using a …