Neuroprotective natural products for Alzheimer's disease

X Chen, J Drew, W Berney, W Lei - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is the number one neurovegetative disease, but its treatment
options are relatively few and ineffective. In efforts to discover new strategies for AD therapy …

Nutraceutical or Pharmacological Potential of Moringa oleifera Lam.

X Kou, B Li, JB Olayanju, JM Drake, N Chen - Nutrients, 2018 - mdpi.com
Moringa oleifera Lam.(M. oleifera), which belongs to the Moringaceae family, is a perennial
deciduous tropical tree, and native to the south of the Himalayan Mountains in northern …

[HTML][HTML] Iron metabolism, ferroptosis, and the links with Alzheimer's disease

N Yan, JJ Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Iron is an essential transition metal for numerous biologic processes in mammals. Iron
metabolism is regulated via several coordination mechanisms including absorption …

[HTML][HTML] Role and mechanism of ferroptosis in neurological diseases

M Ou, Y Jiang, Y Ji, Q Zhou, Z Du, H Zhu, Z Zhou - Molecular Metabolism, 2022 - Elsevier
Background Ferroptosis, as a new form of cell death, is different from other cell deaths such
as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of …

Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease–associated genes

MJ Moulton, S Barish, I Ralhan… - Proceedings of the …, 2021 - National Acad Sciences
A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …

Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review

J Zhang, J Wu, F Liu, L Tong, Z Chen, J Chen… - European journal of …, 2019 - Elsevier
Anthocyanins, a class of water soluble flavonoids extracted from plants like berries and
soybean seed, have been shown to display obvious anti-oxidative, anti-inflammatory, and …

Role of flavonoids in thrombotic, cardiovascular, and inflammatory diseases

CG Vazhappilly, SA Ansari, R Al-Jaleeli… - …, 2019 - Springer
The failure of mechanisms of natural anti-coagulation either due to genetic impairment or
due to severe external injuries may result in a condition called thrombosis. This is believed …

Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases

PB Gonçalves, ACR Sodero, Y Cordeiro - Biomolecules, 2021 - mdpi.com
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …

The neuroprotective effects of astaxanthin: therapeutic targets and clinical perspective

S Fakhri, I Yosifova Aneva, MH Farzaei… - Molecules, 2019 - mdpi.com
As the leading causes of human disability and mortality, neurological diseases affect
millions of people worldwide and are on the rise. Although the general roles of several …

Decrypting the potential role of α-lipoic acid in Alzheimer's disease

D Kaur, T Behl, A Sehgal, S Singh, N Sharma… - Life Sciences, 2021 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases with
motor disturbances, cognitive decline, and behavioral impairment. It is characterized by the …