Extracellular vesicles (EVs) are heterogeneous lipid containers with a complex molecular
cargo comprising several populations with unique roles in biological processes. These …

Parkinson disease (PD) used to be considered a nongenetic condition. However, the
identification of several autosomal dominant and recessive mutations linked to monogenic …

To explore how pathogenic mutations of the multidomain leucine-rich repeat kinase 2
(LRRK2) hijack its finely tuned activation process and drive Parkinson's disease (PD), we …

Mutations in the multidomain protein Leucine-rich-repeat kinase 2 (LRRK2) have been
identified as a genetic risk factor for both sporadic and familial Parkinson's disease (PD) …

Since the discovery of LRRK2 mutations causal to Parkinson's disease (PD) in the early
2000s, the LRRK2 protein has been implicated in a plethora of cellular processes in which …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic forms of Parkinson's disease (PD), for which the LRRK2 locus itself represents a …

Voltage-sensing phosphatase (VSP) exhibits voltage-dependent phosphatase activity
toward phosphoinositides. VSP generates a specialized phosphoinositide environment in …

Vestigial dopaminergic cells in PD have selectivity for a sub-class of hypersensitive neurons
with the nigrostriatal dopamine (DA) tract. DA is modulated in pre-synaptic nerve terminals to …

The multiple hypothesis holds that the pathogenesis of Parkinson's disease (PD) requires
many factors such as heredity, environment and ageing. Mutations in Leucine-rich repeat …

Leucine rich repeat kinase 2 (LRRK2) is the most common genetic contributor to Parkinson's
disease (PD), a complex neurodegenerative disorder affecting nearly 10 million people …