The rapid kinetics of biological processes and associated short-lived conformational
changes pose a significant challenge in attempts to structurally visualize biomolecules …

Finding the conditions to stabilize a macromolecular target for imaging remains the most
critical barrier to determining its structure by cryo-electron microscopy (cryo-EM). While …

Efficient and high-accuracy filtering of cryo-electron microscopy (cryo-EM) micrographs is an
emerging challenge with the growing speed of data collection and sizes of datasets …

Cryo-electron microscopy (cryo-EM) represents a powerful technology for determining
atomic models of biological macromolecules. Despite this promise, human-guided cryo-EM …

Therapeutic antibodies have emerged as a prominent class of new drugs due to their high
specificity and their ability to bind to several protein targets. Once an initial antibody has …

CryoEM multi-grid screening is often a tedious process that demands hours of attention.
Here, this protocol shows how to set up standard Leginon collection and Smart Leginon …

We consider a semi-supervised Reinforcement Learning (RL) approach that takes inputs
from a perception model. Performance of such an approach can be significantly limited by …