Molecular genetic research on bacteriophage lambda carried out during its golden age from
the mid-1950s to mid-1980s was critically important in the attainment of our current …

Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …

Binuclear metallohydrolases are a structurally diverse group of enzymes that use binuclear
metal ion centers to catalyze the hydrolysis of amides and esters of carboxylic and …

ABSTRACT P1 is a bacteriophage of Escherichia coli and other enteric bacteria. It
lysogenizes its hosts as a circular, low-copy-number plasmid. We have determined the …

Purple acid phosphatases (PAPs) catalyze the hydrolysis of a wide range of
phosphomonoester and amide substrates. These enzymes have been identified and …

Phosphoryl and sulfuryl transfer reactions are essential biological processes. Multiple kinetic
isotope effects have provided significant insights into the transition states of these reactions …

Purple acid phosphatases (PAPs) are a family of binuclear metalloenzymes that catalyze the
hydrolysis of phosphoric acid esters and anhydrides. A PAP in sweet potato has a unique …

The retromer complex is responsible for the retrieval of mannose 6-phosphate receptors
from the endosomal system to the Golgi. Here we present the crystal structure of the …

Background Bacteriophage lambda is a model phage for most other dsDNA phages and has
been studied for over 60 years. Although it is probably the best-characterized phage there …

This overview provides an illustrated, comprehensive survey of some commonly observed
protein‐fold families and structural motifs, chosen for their functional significance. It opens …