Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …

The past 20 years have seen dramatic changes in the delivery of radiation therapy, but the
impact of radiobiology on the clinic has been far less substantial. A major consideration in …

Human 53BP1 is primarily known as a key player in regulating DNA double strand break
(DSB) repair choice; however, its involvement in other biological process is less well …

Chromatin is organized into higher-order structures that form subcompartments in
interphase nuclei. Different categories of specialized enzymes act on chromatin and …

Heterochromatin mainly comprises repeated DNA sequences that are prone to ectopic
recombination. In Drosophila cells,'safe'repair of heterochromatic double-strand breaks by …

DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects
of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The …

DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to
ionizing radiation. The repair of DSBs involves both posttranslational modification of …

The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …

Clustered DNA lesions, also called Multiply Damaged Sites, is the hallmark of ionizing
radiation. It is defined as the combination of two or more lesions, comprising strand breaks …

DNA double-strand break (DSB) repair is mediated by multiple pathways. It is thought that
the local chromatin context affects the pathway choice, but the underlying principles are …