DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression

Y Gu, S Niu, Y Wang, L Duan, Y Pan, Z Tong, X Zhang… - Cancer research, 2021 - AACR
Abstract Aberrant N 6-methyladenosine (m6A) modification has emerged as a driver of
tumor initiation and progression, yet how long noncoding RNAs (lncRNA) are involved in the …

[HTML][HTML] IGF2BPs as novel m6A readers: Diverse roles in regulating cancer cell biological functions, hypoxia adaptation, metabolism, and immunosuppressive tumor …

M Duan, H Liu, S Xu, Z Yang, F Zhang, G Wang… - Genes & diseases, 2024 - Elsevier
Abstract m 6 A methylation is the most frequent modification of mRNA in eukaryotes and
plays a crucial role in cancer progression by regulating biological functions. Insulin-like …

Recurrence in localized renal cell carcinoma: a systematic review of contemporary data

JM Speed, QD Trinh, TK Choueiri, M Sun - Current urology reports, 2017 - Springer
Abstract Purpose of Review Patients with localized renal cell carcinoma (RCC) are at risk of
recurrence. The purpose of this review was to characterize the literature on recurrence rates …

IGF2BP3 facilitates cell proliferation and tumorigenesis via modulation of JAK/STAT signalling pathway in human bladder cancer

W Huang, Y Li, C Zhang, H Zha, X Zhou… - Journal of cellular …, 2020 - Wiley Online Library
Insulin‐like growth factor‐2 messenger RNA‐binding protein 3 (IGF2BP3) has been
reported to contribute to tumorigenesis in several human cancers. However, the biological …

The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1-NF-κB signaling axis

Y Wang, J Su, Y Wang, D Fu, JE Ideozu… - Journal of Experimental …, 2019 - Springer
Background Renal cell carcinoma (RCC) is a deadly urological tumor that remains largely
incurable. Our limited understanding of key molecular mechanisms underlying RCC …

LncRNA CDKN2B-AS1 stabilized by IGF2BP3 drives the malignancy of renal clear cell carcinoma through epigenetically activating NUF2 transcription

X Xie, J Lin, X Fan, Y Zhong, Y Chen, K Liu, Y Ren… - Cell death & …, 2021 - nature.com
Because of the lack of sensitivity to radiotherapy and chemotherapy, therapeutic options for
renal clear cell carcinoma (KIRC) are scarce. Long noncoding RNAs (lncRNAs) play crucial …

Renal cell carcinoma: molecular aspects

A Kumar, N Kumari, V Gupta, R Prasad - Indian Journal of Clinical …, 2018 - Springer
Renal cell carcinoma is the most common form of the kidney cancer accounting for more
than 85% of the cases of which clear cell renal cell carcinoma (ccRCC) is the major …

Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy

Y Lai, T Zeng, X Liang, W Wu, F Zhong, W Wu - Cancer cell international, 2019 - Springer
Renal cell carcinoma (RCC) is not sensitive to conventional radio-and chemotherapies and
is at least partially resistant to impairments in cell death-related signaling pathways. The …

Deletion of Insulin-like growth factor II mRNA-binding protein 3 participates in the pathogenesis of recurrent spontaneous abortion by inhibiting IL-10 secretion and …

Y Zhang, F Dai, D Yang, Y Zheng, R Zhu, M Wu… - International …, 2023 - Elsevier
Insulin-like growth factor II mRNA-binding protein 3 (IGF2BP3) has been proved to affect
trophoblast function and embryonic development, but its role and potential mechanism in …

The significance of Notch1 compared with Notch3 in high metastasis and poor overall survival in hepatocellular carcinoma

L Zhou, N Zhang, W Song, N You, Q Li, W Sun… - PloS one, 2013 - journals.plos.org
Background The prognosis for patients with hepatocellular carcinoma (HCC) is poor, and
the mechanisms underlying the development of HCC remain unclear. Notch1 and Notch3 …