Pulmonary defense against environmental injury depends on airway mucus, which traps
inhaled toxins that are then cleared from the lungs by ciliary beating and cough. This review …

Normal airway mucus lines the epithelial surface and provides an important innate immune
function by detoxifying noxious molecules and by trapping and removing pathogens and …

Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene. Although bacterial lung infection and …

In asthma, airflow obstruction is thought to result primarily from inflammation-triggered
airway smooth muscle (ASM) contraction. However, anti-inflammatory and smooth muscle …

Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are
hallmark features of inflammatory airway diseases, including asthma. Here, we show that the …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

Markedly upregulated production of MUC5AC together with stimulated secretion leads to
airflow obstruction in asthma. As MUC5B appears to mediate homeostatic functions, it may …

Mucus hypersecretion is a phenotype associated with multiple obstructive lung diseases.
However, in spite of its nefarious reputation under pathologic conditions, there are …

Asthma is an intractable disease involving the infiltration of inflammatory cells and mucus
plugging. Despite small molecular mucolytics having the ability to break the disulfide bonds …

Airway mucus hypersecretion is a feature of many patients with asthma. It is indicative of
poor asthma control and contributes to morbidity and mortality. Excess mucus not only …