Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Protons dictate the charge and structure of macromolecules and are used as energy
currency by eukaryotic cells. The unique function of individual organelles therefore depends …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Maintaining low levels of sodium ions in the cell cytosol is critical for plant growth and
development. Biochemical studies suggest that Na+/H+ exchangers in the plasma …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Sodium/proton antiporters or exchangers (NHE) are integral membrane proteins present in
most, if not all, living organisms. In mammals, these transporters chiefly catalyze the …

Abstract Sodium/proton exchanger 1 (NHE1) is an electroneutral secondary active
transporter present on the plasma membrane of most mammalian cells and plays critical …

▪ Abstract The sodium/hydrogen exchange (NHE) gene family plays an integral role in
neutral sodium absorption in the mammalian intestine. The NHE gene family is comprised of …

Abstract The Salt Overly Sensitive (SOS) pathway plays an important role in the regulation of
Na+/K+ ion homeostasis and salt tolerance in Arabidopsis thaliana. Previously, we reported …

The mammalian NHE (Na+/H+ exchanger) is a ubiquitously expressed integral membrane
protein that regulates intracellular pH by removing a proton in exchange for an extracellular …