Neurodegenerative diseases result in a range of conditions depending on the type of
proteinopathy, genes affected or the location of the degeneration in the brain …

Purpose Alzheimer's disease (AD) is the most common form of tauopathy that usually
occursduring aging and unfolded protein response (UPR), oxidative stress and autophagy …

Comprehensive expression quantitative trait loci studies have been instrumental for
understanding tissue-specific gene regulation and pinpointing functional genes for disease …

The prevention of protein condensates has emerged as a new drug target to treat diverse
neurodegenerative disorders. We previously reported that terazosin (TZ), a prescribed …

Autophagy targets cytoplasmic materials for degradation, and influences cell health.
Alterations in Atg6/Beclin-1, a key regulator of autophagy, are associated with multiple …

Background Neuronal damage is the main cause of neurological diseases. Neural stem
cells (NSCs) have the functions of cell repair and replacement of neurons, secretion of …

Alzheimer's disease (AD) is the prevailing form of dementia. Protein degradation and
antioxidant pathways have a critical role in preventing the accumulation of protein …

Two major pathological hallmarks of Alzheimer's disease (AD) are amyloid plaques and
neurofibrillary tangles of hyperphosphorylated tau. Aggregation of amyloid-β (Aβ) is …