Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …

Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated
successfully with surgery alone and survival rates are high, but after metastasis survival …

Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms
governing metastatic spread may uncover important tumor biology and/or yield promising …

Estrogens have historically been associated with female reproduction, but work over the last
two decades established that estrogens and their main nuclear receptors (ESR1 and ESR2) …

Since the completion of the first human genome sequence and the advent of next generation
sequencing technologies, remarkable progress has been made in understanding the …

The systemic spread of tumor cells is the ultimate cause of the majority of deaths from
cancer, yet few successful therapeutic strategies have emerged to specifically target …

Abstract Purpose: Anti–programmed death-1 (PD-1) receptor–based therapeutics improve
survival in patients with recurrent head and neck squamous cell carcinoma (HNSCC), but …

Uveal melanoma is a clinically distinct and particularly lethal subtype of melanoma
originating from melanocytes in the eye. Here, we performed multi-region DNA sequencing …