Sculpting with stem cells: how models of embryo development take shape

JV Veenvliet, PF Lenne, DA Turner, I Nachman… - …, 2021 - journals.biologists.com
During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …

[HTML][HTML] Understanding laterality disorders and the left-right organizer: Insights from zebrafish

K Forrest, AC Barricella, SA Pohar… - Frontiers in Cell and …, 2022 - frontiersin.org
Vital internal organs display a left-right (LR) asymmetric arrangement that is established
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …

[HTML][HTML] Bioelectric stimulation controls tissue shape and size

G Shim, IB Breinyn, A Martínez-Calvo, S Rao… - Nature …, 2024 - nature.com
Epithelial tissues sheath organs and electro-mechanically regulate ion and water transport
to regulate development, homeostasis, and hydrostatic organ pressure. Here, we …

[HTML][HTML] Linear viscoelastic properties of the vertex model for epithelial tissues

S Tong, NK Singh, R Sknepnek… - PLoS computational …, 2022 - journals.plos.org
Epithelial tissues act as barriers and, therefore, must repair themselves, respond to
environmental changes and grow without compromising their integrity. Consequently, they …

[HTML][HTML] Nonlinear rheology of cellular networks

C Duclut, J Paijmans, MM Inamdar, CD Modes… - Cells & …, 2021 - Elsevier
Morphogenesis depends crucially on the complex rheological properties of cell tissues and
on their ability to maintain mechanical integrity while rearranging at long times. In this paper …

[HTML][HTML] Differences in boundary behavior in the 3D vertex and Voronoi models

E Lawson-Keister, T Zhang, F Nazari… - PLoS computational …, 2024 - journals.plos.org
An important open question in the modeling of biological tissues is how to identify the right
scale for coarse-graining, or equivalently, the right number of degrees of freedom. For …

Tuning for fluidity using fluctuations in biological tissue models

S Arzash, I Tah, AJ Liu, ML Manning - arXiv preprint arXiv:2312.11683, 2023 - arxiv.org
How do biological systems tune emergent properties at the scale of tissues? One class of
such emergent behaviors, important to biological functions such as body-axis elongation …

[HTML][HTML] The whole is greater than the sum of its parts: large-scale phenomena arising from small-scale biophysical processes

JD Wheeler, KYK Chan - Integrative and Comparative Biology, 2023 - academic.oup.com
The symposium “Large-scale biological phenomena arising from small-scale biophysical
processes” at the SICB 2023 Annual General Meeting focused on the cross-disciplinary …

[HTML][HTML] Polarized interfacial tension induces collective migration of cells, as a cluster, in a 3D tissue

S Okuda, K Sato - Biophysical Journal, 2022 - cell.com
In embryogenesis and cancer invasion, cells collectively migrate as a cluster in 3D tissues.
Many studies have elucidated mechanisms of either individual or collective cell migration on …

Yielding and plasticity in amorphous solids

L Berthier, G Biroli, ML Manning, F Zamponi - arXiv preprint arXiv …, 2024 - arxiv.org
The physics of disordered media, from metallic glasses to colloidal suspensions, granular
matter and biological tissues, offers difficult challenges because it often occurs far from …