Sculpting with stem cells: how models of embryo development take shape
During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …
impose geometrical, mechanical and biochemical constraints. A detailed integrative …
[HTML][HTML] Understanding laterality disorders and the left-right organizer: Insights from zebrafish
K Forrest, AC Barricella, SA Pohar… - Frontiers in Cell and …, 2022 - frontiersin.org
Vital internal organs display a left-right (LR) asymmetric arrangement that is established
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …
[HTML][HTML] Bioelectric stimulation controls tissue shape and size
Epithelial tissues sheath organs and electro-mechanically regulate ion and water transport
to regulate development, homeostasis, and hydrostatic organ pressure. Here, we …
to regulate development, homeostasis, and hydrostatic organ pressure. Here, we …
[HTML][HTML] Linear viscoelastic properties of the vertex model for epithelial tissues
S Tong, NK Singh, R Sknepnek… - PLoS computational …, 2022 - journals.plos.org
Epithelial tissues act as barriers and, therefore, must repair themselves, respond to
environmental changes and grow without compromising their integrity. Consequently, they …
environmental changes and grow without compromising their integrity. Consequently, they …
[HTML][HTML] Nonlinear rheology of cellular networks
Morphogenesis depends crucially on the complex rheological properties of cell tissues and
on their ability to maintain mechanical integrity while rearranging at long times. In this paper …
on their ability to maintain mechanical integrity while rearranging at long times. In this paper …
[HTML][HTML] Differences in boundary behavior in the 3D vertex and Voronoi models
E Lawson-Keister, T Zhang, F Nazari… - PLoS computational …, 2024 - journals.plos.org
An important open question in the modeling of biological tissues is how to identify the right
scale for coarse-graining, or equivalently, the right number of degrees of freedom. For …
scale for coarse-graining, or equivalently, the right number of degrees of freedom. For …
Tuning for fluidity using fluctuations in biological tissue models
How do biological systems tune emergent properties at the scale of tissues? One class of
such emergent behaviors, important to biological functions such as body-axis elongation …
such emergent behaviors, important to biological functions such as body-axis elongation …
[HTML][HTML] The whole is greater than the sum of its parts: large-scale phenomena arising from small-scale biophysical processes
JD Wheeler, KYK Chan - Integrative and Comparative Biology, 2023 - academic.oup.com
The symposium “Large-scale biological phenomena arising from small-scale biophysical
processes” at the SICB 2023 Annual General Meeting focused on the cross-disciplinary …
processes” at the SICB 2023 Annual General Meeting focused on the cross-disciplinary …
[HTML][HTML] Polarized interfacial tension induces collective migration of cells, as a cluster, in a 3D tissue
In embryogenesis and cancer invasion, cells collectively migrate as a cluster in 3D tissues.
Many studies have elucidated mechanisms of either individual or collective cell migration on …
Many studies have elucidated mechanisms of either individual or collective cell migration on …
Yielding and plasticity in amorphous solids
The physics of disordered media, from metallic glasses to colloidal suspensions, granular
matter and biological tissues, offers difficult challenges because it often occurs far from …
matter and biological tissues, offers difficult challenges because it often occurs far from …