Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and
gustatory taste bud cells, where they transmit real-time sensory signals to the brain …

G protein-coupled receptors (GPCRs) conserve common structural folds and activation
mechanisms, yet their ligand spectra and functions are highly diverse. This work …

Smell and taste are among the basic senses with which we perceive the world around us. In
addition to enabling recognition of chemical moieties that provide social or nutritional clues …

Odorant receptors (ORs) are the largest subfamily within class AG protein‐coupled receptors
(GPCRs). No experimental structural data of any OR is available to date and atomic‐level …

Studying the binding processes of G protein-coupled receptors (GPCRs) proteins is of
particular interest both to better understand the molecular mechanisms that regulate the …

Human G-protein coupled receptors (hGPCRs) constitute a large and highly
pharmaceutically relevant membrane receptor superfamily. About half of the hGPCRs' family …

This chapter describes the main characteristics of olfactory receptor (OR) genes of
vertebrates, including generation of this large multigenic family and pseudogenization. OR …

A joint approach combining free‐energy calculations and calcium‐imaging assays on the
broadly tuned human 1G1 olfactory receptor is reported. The free energy of binding of ten …

Olfactory receptors (ORs) represent the largest subfamily of the superfamily G protein‐
coupled receptors (GPCRs). This family of membrane receptors functions as essential …

New atomic-level experimental data on the intermolecular non-covalent interactions
between a common odorant and a relevant residue at odorant binding sites are reported …