Autophagosomes are unique organelles that form de novo as double-membrane vesicles
engulfing cytosolic material for destruction. Their biogenesis involves membrane …

Macroautophagy, hereafter referred to as autophagy, is a complex process in which multiple
membrane‐remodeling events lead to the formation of a cisterna known as the phagophore …

Due to their essential functions, dysregulation of nuclear pore complexes (NPCs) is strongly
associated with numerous human diseases, including neurodegeneration and cancer. On a …

In macroautophagy, cellular components are sequestered within autophagosomes and
transported to lysosomes/vacuoles for degradation. Although phosphatidylinositol 3-kinase …

Lipid droplets (LDs) are fat storage organelles critical for energy and lipid metabolism. Upon
nutrient exhaustion, cells consume LDs via gradual lipolysis or via lipophagy, the en bloc …

Abstract Atg18, Atg21 and Hsv2 are homologous β-propeller proteins binding to PI3P and PI
(3, 5) P2. Atg18 is thought to organize lipid transferring protein complexes at contact sites of …

During macroautophagy, phagophores establish multiple membrane contact sites (MCSs)
with other organelles that are pivotal for proper phagophore assembly and growth. In S …

Eukaryotes utilize different communication strategies to coordinate processes between
different cellular compartments either indirectly, through vesicular transport, or directly, via …

Mitophagy is a specific type of autophagy responsible for the selective elimination of
dysfunctional or superfluous mitochondria, ensuring the maintenance of mitochondrial …

Autophagy is a highly conserved catabolic pathway that maintains cellular homeostasis by
promoting the degradation of damaged or superfluous cytoplasmic material. A hallmark of …