Spirocyclic motifs are emerging privileged structures for drug discovery. They are also
omnipresent in the natural products domain. However, until today, no attempt to analyze the …

Ants (Formicidae) represent a taxonomically diverse group of hymenopterans with over
13,000 extant species, the majority of which inject or spray secretions from a venom gland …

Using stabilized “soft” nucleophiles in copper-catalyzed allylic substitutions is highly
desirable but remains an unsolved challenge for the last 40 years. In this work, a general …

Remote stereocontrol in transition-metal catalysis is a challenging but interesting research
topic. In this work, we achieved copper-catalyzed asymmetric yne-allylic substitution using …

The selective advantage of chemical defenses is evident by its occurrence in many groups
of organisms. Toxic and unpalatable substances are often employed by organisms to avoid …

An air-stable rhodium (I)–oxygen adduct featuring a CNC-pincer ligand, based on 1, 2, 3-
triazol-5-ylidenes, catalyzes the homo-dimerization and hydrothiolation of alkynes, affording …

Sequestration of chemical defenses from dietary sources is dependent on the availability of
compounds in the environment and the mechanism of sequestration. Previous experiments …

Poison frogs sequester chemical defenses from arthropod prey, although the details of how
arthropod diversity contributes to variation in poison frog toxins remains unclear. We …

Amphibians are one of the most remarkable sources of unique natural products. Biogenic
amines, peptides, bufodienolides, alkaloids, and volatile organic compounds have been …

Enynes are important motifs in bioactive compounds. They can be synthesized by alkyne–
alkyne couplings for which a number of mechanisms have been suggested depending on …