The Groebke‐Blackburn‐Bienaymé Reaction

A Boltjes, A Dömling - European Journal of Organic Chemistry, 2019 - Wiley Online Library
Imidazo [1, 2‐a] pyridine is a well‐known scaffold in many marketed drugs, such as
Zolpidem, Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …

Beyond the Ugi reaction: less conventional interactions between isocyanides and iminium species

L El Kaim, L Grimaud - Tetrahedron, 2009 - Elsevier
The history of isocyanide chemistry goes back to the first synthesis of allyl isocyanide by
alkylation of silver cyanide reported by Lieke in 1859. 1 These isomers of cyanides …

Diversity-oriented synthesis of fused-imidazole derivatives via Groebke–Blackburn–Bienayme reaction: a review

N Devi, RK Rawal, V Singh - Tetrahedron, 2015 - Elsevier
In recent time, diversity-oriented synthesis of small chemical entities has been emerged as a
possible tool for exploring the intersections between chemistry and biology. These small …

One-pot synthesis of imidazo [1, 2-a] pyridines from benzyl halides or benzyl tosylates, 2-aminopyridines and isocyanides

M Adib, E Sheikhi, N Rezaei - Tetrahedron letters, 2011 - Elsevier
A one-pot synthesis of imidazo [1, 2-a] pyridines is described. Benzyl halides or benzyl
tosylates are oxidized to aldehydes under mild Kornblum conditions which then undergo a …

Synthesis of oxazolo-, thiazolo-, pyrazolo-, and imidazo-fused heterocycles by multi-component reactions (part 2)

M R. Shaaban, A HM Elwahy - Current Organic Synthesis, 2014 - benthamdirect.com
Development of efficient routes to many kinds of fused heterocycles is an attractive area of
research since these compounds constitute one of the most interesting divisions of organic …

Fast assembly of 1H-imidazo [1, 2-a] imidazol-5-amines via Groebke–Blackburn–Bienaymé reaction with 2-aminoimidazoles

OP Pereshivko, VA Peshkov, DS Ermolat'ev… - Synlett, 2013 - thieme-connect.com
Thieme E-Journals - Synlett / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SYNLETT Full-text search Full-text search Author …

Trimethylsilyl Chloride as a Promoter for the Groebke–Blackburn Reaction: Preparation of Imidazo[2,1-b][1,3]Benzothiazoles

S Tsirulnikov, V Kysil, A Ivachtchenko… - Synthetic …, 2009 - Taylor & Francis
2-Amino [1, 3] benzothiazoles can be efficiently used as substrates for the Groebke–
Blackburn (GB) reaction using equimolar trimethylsilyl chloride (TMSCl) as a promoter. This …

[PDF][PDF] Exploration of the synthesis of imidazo [1, 2-a] pyridin-3-amine derivatives with heteroatom linkers as potential HIV-1 reverse transcriptase inhibitors

SJ MKHIZE - 2022 - wiredspace.wits.ac.za
I, Sandile Mkhize, hereby declare that this work, never been submitted to any university and
for any degree purposes before, is my own work and is hereby submitted to the University of …

Ga (OTf) 3-promoted synthesis of functionalized 2-carbonyl-imidazo [1, 2-a] pyridines derived from ethyl α-benzotriazolyl-α-morpholinoacetate

F Yang, W An, Z Qian, T Yu, Y Du, L Ma, X Wang… - RSC Advances, 2015 - pubs.rsc.org
An efficient route to the synthesis of 3-amino-2-ethoxycarbonyl imidazo [1, 2-a] pyridine
derivatives starting from ethyl α-benzotriazolyl-α-morpholinoacetate has been developed. By …

Development and application of novel scaffolds in drug discovery: the MCR approach

A Boltjes - 2019 - research.rug.nl
Abstract The research André Boltjes described in his thesis covers the application of MCR
methodologies aimed at expansion of the scaffold library and implementation of these …