Immune escape and resistance to immunotherapy in mismatch repair deficient tumors
G Mestrallet, M Brown, CC Bozkus… - Frontiers in …, 2023 - frontiersin.org
Up to 30% of colorectal, endometrial and gastric cancers have a deficiency in mismatch
repair (MMR) protein expression due to either germline or epigenetic inactivation. Patients …
repair (MMR) protein expression due to either germline or epigenetic inactivation. Patients …
The effects of clonal heterogeneity on cancer immunosurveillance
Intratumor heterogeneity (ITH) is associated with tumor progression in several clinical and
experimental settings and contributes to therapeutic resistance. Its relation to cancer …
experimental settings and contributes to therapeutic resistance. Its relation to cancer …
Abundance of reactive oxygen species (ROS) is associated with tumor aggressiveness, immune response, and worse survival in breast cancer
Purpose Reactive oxygen species (ROS) are oxygen-containing molecules that have high
reactivity and play roles in protection or harm the cancer cells. We aimed to clarify the …
reactivity and play roles in protection or harm the cancer cells. We aimed to clarify the …
NR2F1, a tumor dormancy marker, is expressed predominantly in cancer-associated fibroblasts and is associated with suppressed breast cancer cell proliferation
Simple Summary Tumor dormancy is a state in which some cancer cells are dormant by less
cell proliferation, and are resistant to treatments, thus leading to late recurrence. As nuclear …
cell proliferation, and are resistant to treatments, thus leading to late recurrence. As nuclear …
[HTML][HTML] Localization and density of tertiary lymphoid structures associate with molecular subtype and clinical outcome in colorectal cancer liver metastases
C Zhang, XY Wang, JL Zuo, XF Wang… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Tertiary lymphoid structures (TLSs) have been proposed to assess the
prognosis of patients with cancer. Here, we investigated the prognostic value and relevant …
prognosis of patients with cancer. Here, we investigated the prognostic value and relevant …
[HTML][HTML] Elevated bile acid metabolism and microbiome are associated with suppressed cell proliferation and better survival in breast cancer
Bile acids are metabolized by the gut microbiome and are involved in fat absorption.
Contrary to their carcinogenic role in gastrointestinal cancers, bile acids have been reported …
Contrary to their carcinogenic role in gastrointestinal cancers, bile acids have been reported …
[HTML][HTML] Accelerated glycolysis in tumor microenvironment is associated with worse survival in triple-negative but not consistently with ER+/HER2-breast cancer
Metabolic reprogramming to sustain immortality is a hallmark of cancer and glycolysis is an
important way to attain this. Thus, we investigate the association of glycolysis and …
important way to attain this. Thus, we investigate the association of glycolysis and …
[HTML][HTML] Higher intra-tumoral expression of pro-coagulation genes is a predictor of angiogenesis, epithelial mesenchymal transition and worse patient survival in …
Coagulation regulates angiogenesis in cancer, and is associated with tumor development
and metastasis. To date, there have been no studies quantifying the state of intra-tumoral …
and metastasis. To date, there have been no studies quantifying the state of intra-tumoral …
[HTML][HTML] High miR-99b expression is associated with cell proliferation and worse patient outcomes in breast cancer
Although miR-99b is a known suppressive microRNA (miRNA) in several cancers, its role in
breast cancer has not been elucidated. In this study, we examined the clinical relevance of …
breast cancer has not been elucidated. In this study, we examined the clinical relevance of …
From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy
Despite the tremendous clinical successes recorded in the landscape of cancer therapy,
tumor heterogeneity remains a formidable challenge to successful cancer treatment. In …
tumor heterogeneity remains a formidable challenge to successful cancer treatment. In …