Chronic pain is a severely debilitating condition that reflects a long-term sensitization of
signal transduction in the afferent pain pathway. Among the key players in this pathway are …

Trigeminal neuralgia (TN) is a severe facial pain disease of unknown cause and unclear
genetic background. To examine the existing knowledge about genetics in TN, we …

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting
pain daily or on most days. It adversely affects the quality of life and imposes substantial …

OBJECTIVE The goal of this study was to provide a comprehensive overview of the current
understanding of molecular and genetic mechanisms underlying the pathophysiology of …

Chronic pain is a prevalent disease with increasing clinical challenges. Genome-wide
association studies in chronic pain patients have identified hundreds of common pathogenic …

Objective This review aims to systematically summarize the methods of establishing various
models of trigeminal neuralgia (TN), the scope of application, and current animals used in …

Trigeminal neuralgia is a rare and debilitating disorder that affects one or more branches of
the trigeminal nerve, leading to severe pain attacks and a poor quality of life. It has been …

Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …

Epileptic encephalopathies (EEs) are severe brain disorders with excessive ictal (seizure)
and interictal (electrographic epileptiform discharges) activity in developing brain which may …

Trigeminal neuralgia (TN) is a facial pain disorder characterized by intense and paroxysmal
pain that profoundly affects quality of life and presents complex challenges in diagnosis and …