JNK signaling: regulation and functions based on complex protein-protein partnerships
A Zeke, M Misheva, A Reményi… - … and Molecular Biology …, 2016 - Am Soc Microbiol
The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …
Targeting the four pillars of enterohepatic bile salt cycling; lessons from genetics and pharmacology
RF Kunst, HJ Verkade, RPJO Elferink… - Hepatology, 2021 - journals.lww.com
Bile salts play a pivotal role in lipid homeostasis, are sensed by specialized receptors, and
have been implicated in various disorders affecting the gut or liver. They may play a role …
have been implicated in various disorders affecting the gut or liver. They may play a role …
Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex
How neurons develop their morphology is an important question in neurobiology. Here we
describe a new pathway that specifically affects the formation of basal dendrites and axonal …
describe a new pathway that specifically affects the formation of basal dendrites and axonal …
JNK signaling as a target for anticancer therapy
The JNKs are members of mitogen-activated protein kinases (MAPK) which regulate many
physiological processes including inflammatory responses, macrophages, cell proliferation …
physiological processes including inflammatory responses, macrophages, cell proliferation …
Diverse Roles of JNK and MKK Pathways in the Brain
T Yamasaki, H Kawasaki… - Journal of signal …, 2012 - Wiley Online Library
The c‐Jun NH2‐terminal protein kinase (JNK) plays important roles in a broad range of
physiological processes. JNK is controlled by two upstream regulators, mitogen‐activated …
physiological processes. JNK is controlled by two upstream regulators, mitogen‐activated …
Growth cone phosphoproteomics reveals that GAP-43 phosphorylated by JNK is a marker of axon growth and regeneration
Neuronal growth cones are essential for nerve growth and regeneration, as well as for the
formation and rearrangement of the neural network. To elucidate phosphorylation …
formation and rearrangement of the neural network. To elucidate phosphorylation …
MANF is essential for neurite extension and neuronal migration in the developing cortex
KY Tseng, T Danilova, A Domanskyi, M Saarma… - eneuro, 2017 - eneuro.org
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum
(ER) resident protein with neuroprotective effects. Previous studies have shown that MANF …
(ER) resident protein with neuroprotective effects. Previous studies have shown that MANF …
Contrast‐Enhanced Ultrasonography–Based Hepatic Perfusion for Early Prediction of Prognosis in Acute Liver Failure
H Kuroda, T Abe, Y Fujiwara, T Nagasawa, Y Suzuki… - Hepatology, 2021 - journals.lww.com
Hepatocyte Mitogen‐Activated Protein Kinase Kinase 7 Contrib... : Hepatology Hepatocyte
Mitogen‐Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma …
Mitogen‐Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma …
c-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance
The JNK family of MAPKs is involved in a large variety of physiological and pathological
processes in brain development, such as neural survival, migration, and polarity as well as …
processes in brain development, such as neural survival, migration, and polarity as well as …
Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons
YV Nishimura, M Shikanai, M Hoshino… - …, 2014 - journals.biologists.com
Neuronal migration is crucial for development of the mammalian-specific six-layered
cerebral cortex. Migrating neurons are known to exhibit distinct features; they form a …
cerebral cortex. Migrating neurons are known to exhibit distinct features; they form a …