This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

Schizophrenia has been primarily associated with dopamine dysfunction, and treatments
have been developed that target the dopamine pathway in the central nervous system …

Addressing global mental health is a major 21st-century challenge. Current treatments have
recognized limitations; in this context, new ones that are prophylactic and effective across …

This article provides an overview of compounds based on imidazo [1, 2-a] pyridine, imidazo
[1, 5-a] pyridine, imidazo [4, 5-b] pyridine and imidazo [4, 5-c] pyridine scaffolds, which act as …

Introduction There are several new and emerging antipsychotic medication strategies
recently marketed or under clinical development for the treatment of several mental …

There is a considerable overlap between Parkinson's Disease Dementia (PDD) and
Dementia with Lewy Bodies (DLB). They present a challenge therapeutically, with regard to …

Schizophrenia is a major mental illness associated with profound disability. Current
treatments for schizophrenia (antipsychotics) all have a similar mechanism of action and are …

Introduction: The authors describe the medications for treatment-resistant depression (TRD)
in phase II/III of clinical development in the EU and USA and provide an opinion on how …

Schizophrenia is a multifactorial disorder caused by a combination of genetic variations and
exposure to environmental insults. Sleep and circadian rhythm disturbances are a prominent …

In line with recent clinical trials demonstrating that ondansetron, a 5-HT3 receptor (5-HT3R)
antagonist, ameliorates cognitive deficits of schizophrenia and the known procognitive …