Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants
Heavy metals, which have widespread environmental distribution and originate from natural
and anthropogenic sources, are common environmental pollutants. In recent decades, their …
and anthropogenic sources, are common environmental pollutants. In recent decades, their …
The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review
Background Quercetin, one of the most well-known flavonoids, has been included in human
diet for a long history. The use of quercetin has been widely associated with a great number …
diet for a long history. The use of quercetin has been widely associated with a great number …
Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis
Objective Mercury is a global environmental pollutant and is responsible for several organ
pathophysiology including oxidative stress-induced liver disorders. Therefore, the present …
pathophysiology including oxidative stress-induced liver disorders. Therefore, the present …
Oxidative stress in MeHg-induced neurotoxicity
Methylmercury (MeHg) is an environmental toxicant that leads to long-lasting neurological
and developmental deficits in animals and humans. Although the molecular mechanisms …
and developmental deficits in animals and humans. Although the molecular mechanisms …
Rutin protects mercuric chloride‐induced nephrotoxicity via targeting of aquaporin 1 level, oxidative stress, apoptosis and inflammation in rats
Objective Mercury is a dangerous industrial and environmental pollutant which induces
severe damage in diverse organs in animal and humans. The aim of this study was to …
severe damage in diverse organs in animal and humans. The aim of this study was to …
O‐Glycoside quercetin derivatives: Biological activities, mechanisms of action, and structure–activity relationship for drug design, a review
SR Alizadeh, MA Ebrahimzadeh - Phytotherapy Research, 2022 - Wiley Online Library
Quercetin as a valuable natural flavonoid has shown extensive biological activities,
including anticancer, antioxidant, antibacterial, antiinflammatory, anti‐Alzheimer, antifungal …
including anticancer, antioxidant, antibacterial, antiinflammatory, anti‐Alzheimer, antifungal …
Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines
S Wang, YJ Wang, Y Su, W Zhou, S Yang, R Zhang… - Neurotoxicology, 2012 - Elsevier
Alzheimer's disease (AD) is a complex, multi-factorial neurodegenerative disease. The
aggregation of soluble β-amyloid (Aβ) into fibrillar deposits is a pathological hallmark of AD …
aggregation of soluble β-amyloid (Aβ) into fibrillar deposits is a pathological hallmark of AD …
Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals
G Bjørklund, H Antonyak, A Polishchuk… - Archives of …, 2022 - Springer
Methylmercury (MeHg) is a global environmental pollutant with neurotoxic effects. Exposure
to MeHg via consumption of seafood and fish can severely impact fetal neurobehavioral …
to MeHg via consumption of seafood and fish can severely impact fetal neurobehavioral …
Antioxidant activity, genotoxicity and cytotoxicity evaluation of lemon balm (Melissa officinalis L.) ethanolic extract: Its potential role in neuroprotection
JP Kamdem, A Adeniran, AA Boligon… - Industrial Crops and …, 2013 - Elsevier
The antioxidant activity of Melissa officinalis (MO) was evaluated to understand the
mechanism of its pharmacological properties as well as its potential genotoxic and cytotoxic …
mechanism of its pharmacological properties as well as its potential genotoxic and cytotoxic …
Neuroprotective effects of rutin in streptozotocin-induced diabetic rat retina
Diabetic retinopathy is widely recognized as a neurodegenerative disease of the eye.
Increased oxidative stress has been considered the central factor in damaging neural retina …
Increased oxidative stress has been considered the central factor in damaging neural retina …