Computational prediction of intrinsic disorder in protein sequences dates back to late 1970
and has flourished in the last two decades. We provide a brief historical overview, and we …

Thrombin is the key enzyme of the entire hemostatic process since it is able to exert both
procoagulant and anticoagulant functions; therefore, it represents an attractive target for the …

Malaria begins when an infected mosquito injects saliva containing Plasmodium sporozoites
into the skin of a vertebrate host. To prevent malaria, vaccination is the most effective …

Madanin-1 and chimadanin are two small cysteine-free thrombin inhibitors that facilitate
blood feeding in the tick Haemaphysalis longicornis. Here, we report a post-translational …

Thromboembolism and its sequelae have been the leading causes of morbidity and
mortality throughout the world. Food-derived antithrombotic peptides, as potential …

Except for honey as food, and silk for clothing and pollination of plants, people give little
thought to the benefits of insects in their lives. This overview briefly describes significant …

Conspectus Tyrosine sulfation is a post-translational modification (PTM) that modulates
function by mediating key protein–protein interactions. One of the early proteins shown to …

Background Mosquito saliva is a complex cocktail whose pharmacological properties play
an essential role in blood feeding by counteracting host physiological response to tissue …

Arthropod-borne viruses present important public health challenges worldwide. Viruses
such as DENV, ZIKV, and WNV are of current concern due to an increasing incidence and …

The anophelins are small protein thrombin inhibitors that are produced in the salivary glands
of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of …