Neutrophils as regulators of cardiovascular inflammation

C Silvestre-Roig, Q Braster, A Ortega-Gomez… - Nature Reviews …, 2020 - nature.com
Neutrophils have traditionally been viewed as bystanders or biomarkers of cardiovascular
disease. However, studies in the past decade have demonstrated the important functions of …

Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation

AJ Mouton, X Li, ME Hall, JE Hall - Circulation research, 2020 - Am Heart Assoc
Obesity and hypertension, which often coexist, are major risk factors for heart failure and are
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …

[HTML][HTML] A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis

S Ahmadi, S Wang, R Nagpal, B Wang, S Jain… - JCI insight, 2020 - ncbi.nlm.nih.gov
Inflammation is a major risk factor of morbidity and mortality in older adults. Although its
precise etiology is unknown, low-grade inflammation in older adults is commonly associated …

Dietary supplements and nutraceuticals under investigation for COVID-19 prevention and treatment

R Lordan, HM Rando, CS Greene - Msystems, 2021 - Am Soc Microbiol
ABSTRACT Coronavirus disease 2019 (COVID-19) has caused global disruption and a
significant loss of life. Existing treatments that can be repurposed as prophylactic and …

Neutrophils actively contribute to obesity-associated inflammation and pathological complications

E Uribe-Querol, C Rosales - Cells, 2022 - mdpi.com
Obesity is characterized by an increase in body weight associated with an exaggerated
enlargement of the adipose tissue. Obesity has serious negative effects because it is …

Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on …

D Tousoulis, T Guzik, T Padro, DJ Duncker… - Cardiovascular …, 2022 - academic.oup.com
The human gut microbiota is the microbial ecosystem in the small and large intestines of
humans. It has been naturally preserved and evolved to play an important role in the …

Gut microbiota in heart failure patients with preserved ejection fraction (GUMPTION study)

Z Huang, X Mei, Y Jiang, T Chen… - Frontiers in cardiovascular …, 2022 - frontiersin.org
Introduction: Heart failure with preserved ejection fraction (HFpEF) is associated with
disrupted intestinal epithelial function, resulting from intestinal congestion. Intestinal …

Extrinsic and intrinsic modulators of inflammation-resolution signaling in heart failure

A Rao, A Gupta, V Kain… - American Journal of …, 2023 - journals.physiology.org
Chronic and uncleared inflammation is the root cause of various cardiovascular diseases.
Fundamentally, acute inflammation is supportive when overlapping with safe clearance of …

Molecular and cellular differences in cardiac repair of male and female mice

AB Pullen, V Kain, CN Serhan… - Journal of the American …, 2020 - Am Heart Assoc
Background Leukocyte‐directed biosynthesis of specialized proresolving mediators (SPMs)
orchestrates physiological inflammation after myocardial infarction. Deficiency of SPMs …

Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now?

OS Ahmed, JM Galano, T Pavlickova… - Essays in …, 2020 - portlandpress.com
Polyunsaturated fatty acids (PUFAs) are essential components in eukaryotic cell membrane.
They take part in the regulation of cell signalling pathways and act as precursors in …